Receiving multi-vitamins supplementation (B6, B9, D, E, Q10) for 6 months trial

Epilepsy

Vitamin B6:100 mg/day Vitamin B9: 5 mg/day Vitamin D: 1000 IU/day Vitamin E: 400 IU/day Co-Q10: 100 mg/day

Multi-vitamin supplementation

National Cheng Kung University (NCKU) Hospital

Exploring the Effects of Genetic Variants and Inflammation on Vitamins Supplementation Treatment Outcomes in Epilepsy

Exploring the Effects of Genetic Variants and Inflammation on Individualized Treatment Outcomes of Vitamins Supplementation in Patient With Epilepsy

Assessing using Morisky Medication Adherence Scale (MMAS)

National Cheng-Kung University Hospital

20 pregnant women with previous gastric bypass surgery. During pregnancy the women will be tested with mixed meal test and continuous glucose monitoring for the diagnosis of hypoglycemia. Ultrasounds of fetal growth will be performed and after birth anthropometrics of the newborn will be meaured including a DXA-scan to estimate bodycomposition.

20 pregnant women matched on age, prepregnancy-BMI and parity (n = 20). During pregnancy the women will be tested with mixed meal test and continuous glucose monitoring for the diagnosis of hypoglycemia. Ultrasounds of fetal growth will be performed and after birth anthropometrics of the newborn will be meaured including a DXA-scan to estimate bodycomposition.

Hypoglycemia Non-Diabetic

Gastric Bypass Status Complicating Pregnancy, Birth, or Puerperium

All women will have mixed meal test, continous glucose monitoring and antenatal ultrasounds performed. The children born of these women will have DXA-scans performed after birth.

Mixed meal test

Odense University Hospital

Hospital of South West Jutland

Pregnancy Following Gastric Bypass - Consequences for Mother and Child

The Effect of Gastric Bypass Surgery on Glucose Metabolism, Gestational Weight Gain and Fetal Growth in Subsequent Pregnancy

Nadir plasma glucose levels during a 4-hour liquid MMT

Number of hypoglycemic episodes during CGM

Louise Stentebjerg

Principal investiagtor, MD, PhD-student

University of Southern Denmark

Patients presenting to the ED with suspected sepsis who develop altered mental status

Patients presenting to the ED with suspected sepsis without change in mental status

Patients presenting to the ED with no suspicion of systemic inflammation that need hospitalization (control category)

Sepsis

Altered Mental Status

Sepsis-Associated Delirium

Sepsis Associated Encephalopathy

Delirium, Sepsis Associated

Blood draws will be collected via venipuncture or IV at hours 0, 6, 12, 18, 24, 48, 72 (7 draws total). Each draw would be up to 20 mL of blood (but no less than 10 mL).

Blood draws

University of Florida

Sepsis Associated Encephalopathy (SAE) Biomarkers

Serum Biomarkers in Sepsis Associated Encephalopathy (SAE)

Acute encephalopathy will be measured using the mental status assessment including the Delirium Triage Screen (DTS) Brief Confusion Assessment Method (bCAM). DTS-bCAM assessment is a flowchart that helps diagnose a patient who is altered.

Acute encephalopathy will be measured using the mental status assessment short blessed test (SBT). Sum Total (range 0-28) [0-4 = normal cognition, 5-9 = questionable impairment, ≥ 10 = Impairment consistent with dementia]

Organ dysfunction will be assessed using Sequential Organ Failure Assessment (SOFA) methodology, a mortality assessment tool that monitors the dynamics of cardiovascular, respiratory, neurological, renal, hepatic, and hematological organ function.

Date of death will be recorded for all patients who died during the study period. Rate of survival will be assessed.

assessed using the Cerebral Performance Category (CPC) scoring [CPC 1: A return to normal cerebral function and normal living, CPC 2: Cerebral disability but sufficient function for independent activities of daily living, CPC 3: Severe disability, limited cognition, inability to carry out independent existence, CPC 4: Coma, CPC 5: Brain death

Cognitive Failure Questionnaire (CFQ) sum of 25 questions, range 0-100 assessing Forgetfulness, Distractibility, and False Triggering

Anemia

Renal Failure, Chronic Renal Failure

Epoetin alfa

Effect of Early Correction Of Anaemia on the Progression of Chronic Renal Insufficiency (ECAP)

avitaminosis/seizures

Exploring the Effects of Genetic Variants and Inflammation on Vitamins Supplementation Treatment Outcomes in Epilepsy

Pregnancy Following Gastric Bypass - Consequences for Mother and Child

Sepsis Associated Encephalopathy (SAE) Biomarkers

Effects of Early Correction of Anemia in Patients With Chronic Renal Insufficiency

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