The present invention provides uses of chlorogenic acid in the preparation of medicaments for treatment of oligodendroglioma. Chlorogenic acid according to the present invention has an inhibitory action against oligodendroglioma, and can inhibit the growth of brain tumor stem cells, thus can partly substitute chemoradiation. Chlorogenic acid can alleviate the unwell response of patients caused by chemoradiation, and become a new medicinal therapeutic means and choose for treatment of oligodendroglioma.

SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD

SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD.

Uses of chlorogenic acid in the preparation of medicaments for treatment of oligodendroglioma

A preparation containing a chlorogenic acid crystal form. The crystal form is an orthorhombic crystal system, a space group is P2.sub.12.sub.12.sub.1, cell parameters are as follows: a=7.7291(2).ANG., b=10.9808(2).ANG., c=36.5334(7).ANG., .alpha.=.beta.=.gamma.=90.00.degree., Z=8, and a cell volume is 3100.65(11).ANG.3. The content of the chlorogenic acid crystal form in the preparation is 10-5000 mg/g. The preparation is advantageous to bioavailability, and can be used for preparing medicines for treating tumor, psoriasis and other immune system diseases, resisting oxidation, protecting liver and gallbladder, treating cardiovascular diseases, and resisting viruses.

Preparation containing chlorogenic acid crystal form and use thereof

An extract from green coffee beans is disclosed which contains polyphenols and bioactive compounds e.g. Chlorogenic acids in a significantly higher concentration (70-80%) than in extracts of prior art methods (40-50%). The extract has greater ability to quench oxidative stress and destroy free radicals and offers health benefits due to its anti-obesity, anti-diabetic, antihypertensive, anti-tumor and anti-acid properties. The higher concentration of bioactive compounds has been achieved by use of polar solvents having polarity less than that of alcohols used for extraction. The use of such solvents of lower polarity such as n-Butyl alcohol, ethyl acetate or acetone results in extraction of enriched Chlorogenic acid fractions into the extract, leaving polar impurities behind in aqueous medium. The extract obtained has significantly higher content of polyphenols and chlorogenic acids ranging from 70-80% and a distinctive HPLC profile.

chlorogenic acid/rak

Uses of chlorogenic acid in the preparation of medicaments for treatment of oligodendroglioma

Preparation containing chlorogenic acid crystal form and use thereof

Method for extracting high content of chlorogenic acids from green coffee beans

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