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chloroquine/atrofija
Veza se sprema u međuspremnik
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A type of macular degeneration in adult Nigerians; a possible role of chloroquine.
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Eleven cases of macular degeneration occurring between the ages of 22 years and 40 years are presented. All the patients gave positive history of chloroquine intake and outdoor activity. In 4 of the 11 cases, pterygium was an associated ocular finding. The female to male ratio was 3 to 1. The
Chloroquine inhibits autophagy and deteriorates the mitochondrial dysfunction and apoptosis in hypoxic rat neurons.
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OBJECTIVE
Mitochondrial dysfunction (MD) and apoptosis in the neurons are associated with neonatal hypoxic-ischemic (HI) encephalopathy (HIE). The present study was to explore the influence of autophagy on the induction of MD and apoptosis in the neurons in a neonatal HIE rats and in hypoxia-treated
Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration.
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BACKGROUND
Age-related macular degeneration (AMD) is the leading cause of vision loss in elderly people over 60. The pathogenesis is still unclear. It has been suggested that lysosomal stress may lead to drusen formation, a biomarker of AMD. In this study, ARPE-19 cells were treated with chloroquine
Progressive optical coherence tomography deterioration in chloroquine maculopathy.
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OBJECTIVE
To report optical coherence tomography (OCT) progressive changes in chloroquine maculopathy.
METHODS
Observational case report.
METHODS
Both eyes of a patient with chloroquine maculopathy were examined serially with OCT.
RESULTS
OCT demonstrated diffuse retinal thinning involving the fovea
Chloroquine macular degeneration.
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Bilateral macular degeneration associated with chloroquine therapy.
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ANOTHER CASE OF MACULAR DEGENERATION DUE TO CHLOROQUINE.
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[Studies on drug-induced retinal degeneration. 2. Changes in fine structures of inner layers of the retina in experimental chloroquine retinopathy].
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[Studies on drug-induced retinal degeneration. Part 3. Long-term observation on chloroquine retinopathy (author's transl)].
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Persistent dermal degeneration after chloroquine-cure of chronic discoid Iupus erythematosus.
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Persistent dermal degeneration after chloroquine-cure of chronic discoid lupus erythematosus.
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[Chloroquine retinopathy and unilateral sectoral pigmentary degeneration of the retina (author's transl)].
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[Studies on drug-induced retinal degeneration. I. Early stages of experimental chloroquine retinopathy].
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Shunt reversal due to deterioration of chloroquine-induced cardiomyopathy in a patient with primary Sjögren syndrome.
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Chloroquine-induced lipidosis in the rat retina: a functional and morphological study.
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Corneal opacity, reversible retinal lipidosis and irreversible receptor cell degeneration are known to occur after long-term treatment with chloroquine. Female albino Wistar rats (initial age 6 weeks, weight between 100 and 150 g) were treated orally with chloroquine (40-60 mg/kg body weight) for 4
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