Ibudilast

Placebo

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Baseline methamphetamine use on 26 or more days per month

End of treatment methamphetamine abstinence

Methamphetamine Use

Overall Study

Keith Heinzerling MD

Methamphetamine Dependence

HIV Infection

UCLA Vine Street Clinic

Trial of Ibudilast for Methamphetamine Dependence

Randomized Trial of Ibudilast for Methamphetamine Dependence

Keith Heinzerling

Associate Professor in Residence

University of California, Los Angeles

National Institute on Drug Abuse (NIDA)

Athletic Performance

guanidinoacetic acid

GAA-4

GAA-1

PLACEBO

Biomedical Scinces Department, Exercise Physiology Lab

Guanidinoacetic Acid (GAA) Administration in Physically Active Men and Women

The Effects of Medium-term Oral Guanidinoacetic Acid (GAA) Administration on Human Performance, Body Composition, and Metabolic Outcomes in Physically Active Men and Women

The majority of investigations involving the effects of creatine (or creatine precursors) supplementation on human performance were laboratory-based and have focused on musucular strength and power and anaerobic endurance, with various task protocols such as weght lifting, running, jumping and cycling less than or equal to 30 sec in duration. Similarly, the effects of GAA on exercise performance should be investigated with measuring muscle strength and power (through both isometric and isotonic exercise) and anaerobic endurance (e.g. repeated jumping performance).

A creatine supplementation-induced increase in body mass, particularly if not muscle mass, could be detrimental to performance in sports in which the body mass needs to be moved efficiently from one point to another. If GAA acts as creatine, which is an osmotically active substance, an increase in intracellular creatine concentration may likely induce influx of water into the cell. Therefore, changes of body mass and body composition (particularly muscle mass) after GAA intake should be monitored during the present study.

cicer canariense/upala

Trial of Ibudilast for Methamphetamine Dependence

Guanidinoacetic Acid (GAA) Administration in Physically Active Men and Women

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