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covid-19/hypoxia

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Can Hyperperfusion of Nonaerated Lung Explain COVID-19 Hypoxia?

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Early stages of the novel coronavirus disease (COVID-19) have been associated with 'silent hypoxia' and poor oxygenation despite relatively small fractions of afflicted lung. Although it has been speculated that such paradoxical findings may be explained by impairment of hypoxic pulmonary

Proposal for Initiative of Evidence-based Treatment of COVID-19 Patients with Worsening Hypoxia

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The global spread of COVID-19 resulting in severe Acute Respiratory Syndrome was classified by the WHO as pandemic in March 2020. Coronavirus (Covid-19) is an ongoing pandemic of coronavirus disease 2019 (COVID 19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV 2). The disease

Is hypoxemia explained by intracardiac or intrapulmonary shunt in COVID-19-related acute respiratory distress syndrome?

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Hypoxemia is the main feature of COVID-19-related acute respiratory distress syndrome (C-ARDS), but its underlying mechanisms are debated, especially in patients with low respiratory system elastance (Ers). We assessed 60 critically ill patients hospitalized in our intensive care unit for C-ARDS. We

Hypoxemia Index Associated with Prehospital Intubation in COVID-19 Patients

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Background: There exists a need for prognostic tools for the early identification of COVID-19 patients requiring prehospital intubation. Here we investigated the association between a prehospital Hypoxemia Index (HI) and the need for

Silent Hypoxia in Patients with SARS CoV-2 Infection before Hospital Discharge

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Objective: To assess the degree of hypoxia and subjective dyspnoea elicited by a 6-minute walking test (6 MWT) in COVID-19 patients prior to discharge. Methods: A 6 MWT was

Happy Hypoxemia in COVID-19-A Neural Hypothesis

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Many COVID-19 patients are presenting with atypical clinical features. Happy hypoxemia with almost normal breathing, anosmia in the absence of rhinitis or nasal obstruction, and ageusia are some of the reported atypical clinical findings. Based on the clinical manifestations of the disease, we are
Patients with coronavirus disease 2019 (COVID-19) seldom complain of dyspnea. It has been suggested that the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) targets the brainstem and plays a role COVID-19 respiratory failure. We hypothesise that asymptomatic hypoxemia presented by

Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?

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A very recent epidemiological study provides preliminary evidence that living in habitats located at 2500 m above sea level (masl) might protect from the development of severe respiratory symptoms following infection with the novel SARS-CoV-2 virus. This epidemiological finding raises the question

The pathophysiology of 'happy' hypoxemia in COVID-19

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The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet without proportional signs of respiratory distress (i.e. happy hypoxemia) and rapid
Coronavirus disease (COVID-19) is a severe infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to the cells; angiotensin converting enzyme 2 (ACE2) receptor. In the first severe case of COVID-19 in Shenzhen city, we found that in addition to the

Hypoxia response and acute lung and kidney injury: possible implications for therapy of COVID-19

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Coronavirus disease 2019 (COVID-19) is a pandemic of unprecedented severity affecting millions of people around the world and causing several hundred thousands of deaths. The presentation of the disease ranges from asymptomatic manifestations through to acute respiratory distress syndrome with the

Identification of Exertional Hypoxia and Its Implications in SARS-CoV-2 Pneumonia

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Identification of Exertional Hypoxia and Its Implications in SARS-CoV-2 Pneumonia.

Plasminogen improves lung lesions and hypoxemia in patients with COVID-19.

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Lungs from patients with coronavirus disease 2019 (COVID-19) have shown typical signs of acute respiratory distress syndrome (ARDS), formation of hyaline membrane mainly composed of fibrin, and 'ground-glass' opacity. Previously, we showed plasminogen itself is a key regulator in

Hypoxemia in COVID-19 patients: An hypothesis

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The current SARS-Cov-2 virus pandemic challenges critical care physicians and other caregivers to find effective treatment for desperately ill patients - especially those with sudden and extreme hypoxemia. Unlike patients with other forms of Acute Respiratory Distress Syndrome, these patients do not

Silent hypoxia: A harbinger of clinical deterioration in patients with COVID-19

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Patients infected with the SARS-CoV-2 virus can present with a wide variety of symptoms including being entirely asymptomatic. Despite having no or minimal symptoms, some patients may have markedly reduced pulse oximetry readings. This has been referred to as "silent" or "apathetic" hypoxia
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