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Resistance of myenteric neurons in the rat's colon to depletion by 1,8-dihydroxyanthraquinone.
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Earlier reports have suggested that anthraquinone purgatives in excessive amounts cause degeneration of neurons in the enteric nervous system. Danthron (1,8-dihydroxyanthraquinone) was administered to rats in their drinking water for four months. The effects of the drug on the total number of
Effects of long-term laxative treatment on neuropeptides in rat mesenteric vessels and caecum.
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In order to investigate the toxic effects of long-term treatment with anthraquinone laxatives, rats were fed either chocolate alone, or chocolate adulterated with senna or danthron (1,8-dihydroxyanthraquinone) for 5 months. Mesenteric blood vessels and the outer muscle layers of the caecum, together
Light and electron-microscopic changes in the colon of the guinea pig after treatment with anthranoid and non-anthranoid laxatives.
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Male guinea pigs were treated with senna pods, sennosides, danthron or bisacodyl by gastric intubation for 14 consecutive days. The animals were then killed and the intestine was evaluated by light and electron-microscopic techniques. Macroscopically, the mucosa of the cecum and upper colon was
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