All healthy control participants will undergo the same screening and experimental procedures. Healthy controls must report no other medical conditions ( including fibromyalgia) to be considered for inclusion. All healthy controls will have an MRI scan performed both before and 3 hours post 0.4ng/kg endotoxin injection.

All fibromyalgia participants will undergo the same screening and experimental procedures. However, fibromyalgia participants will need to meet 2010 American College of Rheumatology diagnostic criteria for fibromyalgia. All fibromyalgia participants will have an MRI scan performed both before and 3 hours post 0.4ng/kg endotoxin injection.

Fibromyalgia

Endotoxin is a purified lipopolysaccharide prepared from E. coli O:113 and vialed under good manufacturing practice guidelines.

Endotoxin, Escherichia Coli

MRI is a non-invasive imaging technique and does not utilize ionizing radiation.

Magnetic Resonance Spectroscopy

University of Alabama at Birmingham

The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia

The concentration of brain metabolite CHO will be measured via MRI scan as a measure of neuroinflammation. This measurement will be performed in both the control and experimental group.

The concentration of brain metabolite MI will be assessed via MRI scan as a measure of neuroinflammation. This measurement will be performed in both the control and experimental group.

The concentration of brain metabolite LAC will be assessed via MRI scan as a measure of neuroinflammation. This measurement will be performed in both the control and experimental group.

The temperature of the brain will be assessed via MRI scan as a measure of neuroinflammation. This measurement will be performed in both the control and experimental group.

Jarred Younger

Assistant Professor

American Fibromyalgia Syndrome Association

Healthy controls and fibromyalgia patients will have an MRI scan both before and 3 hours post endotoxin injection.

Patients who did not have any change or a change less than 4 points between MMT1 and MMT3

Patients with a difference more than 4 points between MMT1 and MMT3

Post Operative Cognitive Dysfunction

Mini Mental Test was used for literate patients and Modified mini mental test was used for illiterated patients

Mini Mental and Modified Mini Mental Test

Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction

Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction in Patients Who Underwent Hip Surgery Under Regional Anesthesia

Burcu Ozalp Horsanali

Burcu OZALP HORSANALI

Each PS 128 capsule contains 300 mg of probiotics. PS128 will be provided 300 mg twice, in the morning and in the afternoon, daily.

Major Depressive Disorder

Inflammation

Probiotics

Lactobacillus plantarum PS128

Taipei Medical University - WanFang Hospital

Lactobacillus Plantarum PS128 in Patients With Major Depressive Disorder and High Level of Inflammation

Psychophysiological Effects of Lactobacillus Plantarum PS128 in Patients With Major Depressive Disorder and High Level of Inflammation: a Pilot Study of 8-week Open Trial

measure serum hs-CRP at baseline, week 4 and week8

measure serum TNF-alpha at baseline, week 4 and week8

measure serum IL-6 at baseline, week 4 and week8

measure serum IL-10 at baseline, week 4 and week8

measure depression rating at baseline, week 2, week 4 and week 8

gut microbiota analyses at baseline and week 8

measure gut permeability at baseline and week 8

measure gut inflammation at baseline and week 8

measure of expression of TLPs at baseline and week 8

encephalitis/nikotin

The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia

Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction

Lactobacillus Plantarum PS128 in Patients With Major Depressive Disorder and High Level of Inflammation

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