BACKGROUND OF THE INVENTION
It has been discovered that the activity of a particular enzyme, polyisoprenylated methylated protein methyl esterase (PMPMEase which is also known as human carboxylesterase 1 or hCE1), is elevated in certain cancers, particularly in breast cancer. The present invention
BACKGROUND OF THE INVENTION
It has been discovered that the activity of a particular enzyme, polyisoprenylated methylated protein methyl esterase (PMPMEase which is also known as human carboxylesterase 1 or hCE1), is elevated in certain cancers, such as in breast cancer. The present invention is
FIELD OF THE INVENTION
The present invention relates to a new class of glucuronides, esters, and glycosides whose aglycone activity is more highly toxic than normally found for such compounds, as well as to methods of preparation of such glucuronides, esters, and glycosides. The present invention
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a tumor marker for diagnosis of cancer, especially for diagnosis of ovarian cancer, which can be applied in early diagnosis of ovarian cancer.
2. The Prior Arts
Human ovarian cancer is one of the common
FIELD OF THE INVENTION
The present invention is directed to a method for treating prostate cancer by administering collagenase alone or in combination with a glycosidase, a protease, a nuclease, a lipase, an esterase, a streptokinase, or a combination thereof. A typical embodiment includes
FIELD OF THE INVENTION
The present invention is directed to a method for treating prostate cancer by administering collagenase alone or in combination with a glycosidase, a protease, a nuclease, a lipase, an esterase, a streptokinase, or a combination thereof. A typical embodiment includes
FIELD OF THE INVENTION
The present invention relates to the therapeutic use of quinolone derivatives, and to certain novel such compounds.
BACKGROUND OF THE INVENTION
Quinolone compounds are known primarily as antibacterial agents (see JP-A-05025162; U.S. Pat. No. 5,037,834; EP-A-0420069;
FIELD OF THE INVENTION
The present invention relates to the therapeutic use of quinolone derivatives, and to certain novel such compounds.
BACKGROUND OF THE INVENTION
Quinolone compounds are known primarily as antibacterial agents (see JP-A-05025162; U.S. Pat. No. 5037834; EP-A-0420069;
BACKGROUND OF THE INVENTION
The present invention relates to cyclophosphamide analogs particularly useful for the suppression of tumor cells.
Since the demonstration in 1942 that nitrogen mustard was effective at inducing remission in patients with lymphoma (A. Gilman (1063) Amer. J. Surg. 105:574),
FIELD OF THE INVENTION
This invention is directed to the use of amide, aryl sulphonamide, aryl urea, and .alpha.,.beta.-diketone compounds as carboxylesterase inhibitors, and particularly to the use of these compounds as selective human intestinal carboxylesterase inhibitors. The compounds are also
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to chemical compounds and methods useful in the regulation of thrombin receptor mediated cell stimulation. More specifically, the invention is directed to prothrombin-derived peptides and methods which employ
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to chemical compounds and methods useful in the regulation of thrombin receptor mediated cell stimulation. More specifically, the invention is directed to prothrombin-derived peptides and methods which employ
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is directed to chemical compounds and methods useful in the regulation of thrombin receptor mediated cell stimulation. More specifically, the invention is directed to prothrombin-derived peptides and methods which employ
BACKGROUND OF THE INVENTION
The present invention relates to cyclophosphamide analogs particularly useful for the suppression of tumor cells.
Since the demonstration in 1942 that nitrogen mustard was effective at inducing remissions in patients with lymphoma (A. Gilman Amer. J. Surg. 105:574),
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