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9 rezultati
Method of treating hyperlipidemia and inflammation with sulfonate derivatives
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This invention relates to sulfonate derivatives.
The sulfonate derivatives of the present invention are novel compounds represented by the formula
wherein R.sub.1 is alkyl having 1 to 4 carbon atoms, alkoxyalkyl having 2 to 6 carbon atoms, aralkyl, cycloalkyl or aryl with or without a substituent
Antilipemic and anti-inflammatory compositions containing sulfonate derivatives
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This invention relates to sulfonate derivatives.
The sulfonate derivatives of the present invention are novel compounds represented by the formula
wherein R.sub.1 is alkyl having 1 to 4 carbon atoms, alkoxyalkyl having 2 to 6 carbon atoms, aralkyl, cycloalkyl or aryl with or without a substituent
Prodrugs of non-steroid anti-inflammatory agents (NSAIDS)
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FIELD OF THE INVENTION
The present invention relates to novel prodrugs of NSAIDs comprising an immobility promoting unit covalently linked, in the form of an ester bond, to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel compounds are soluble at acidic pH but precipitate at
IKK-beta serine-threonine protein kinase inhibitors
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a National Stage application of co-pending PCT application PCT/GB2007/004114 filed Oct. 29, 2007, which claims the benefit of Great Britain application number 0621720.2 filed Nov. 1, 2006 and Great Britain application number 0715470.1 filed
Inhibitors of IKK-beta serine-threonine protein kinase
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a National Stage application of co-pending PCT application PCT/GB2007/004117 filed Oct. 29, 2007, which claims the benefit of Great Britain application number 0621720.2 filed Nov. 1, 2006 and Great Britain application number 0715469.3 filed
Method to reduce myocardial injury during acute myocardial infarction
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FIELD OF THE INVENTION
This invention is in the field of immunology/cardiology/biochemistry, and describes more particularly a method to reduce myocardial cell injury during acute myocardial infarction.
BACKGROUND OF THE INVENTION
Mechanical failure of heart muscle is one of the leading causes of
P38 MAP kinase inhibitors
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a National Stage application of co-pending PCT application PCT/GB2007/001596 filed May 1, 2007, which claims the benefit of Great Britain application number 0608855.3 filed May 4, 2006 and Great Britain application number 0613914.1 filed
Inhibitors of P38 map kinase
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a National Stage application of co-pending PCT application PCT/GB2009/000553 filed Feb. 27, 2009, which application claims priority from Great Britain Application No. 0803748.3 filed Feb. 29, 2008 and Great Britain Application No. 0815544.2
Combination treatment comprising administration of 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahydropyridines
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CROSS REFERENCE TO RELATED APPLICATIONS
This application claims priority to Denmark Patent Applications No. PA201500456 (filed on Aug. 10, 2015) and PA201500707 (filed on Nov. 10, 2015).
FIELD OF THE INVENTION
The present invention provides combinations comprising compounds which act as BACE1
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