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7 rezultati
Massive ovarian edema with androgen secretion. A pathological and endocrine study with review of the literature.
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A case of massive edema of the left ovary with virilization is described. Microscopically, massive interstitial edema with luteinization of theca and stromal cells was found. A few stromal cells contained Reinke-type crystalloids--an original observation. Peripheral concentrations of testosterone,
Factors associated with edema of the mammary gland in primigravid dairy heifers.
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The severity and anatomical extent of mammary edema (edema) of 73 primigravid Holstein heifers was scored, and certain hormones in peripheral blood plasma were quantified. The objective was to obtain by least-squares analysis of covariance independent estimates of the association of each hormone and
Efficacy and local tolerance of a low-dose, 7-day matrix estradiol transdermal system in the treatment of menopausal vasomotor symptoms.
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OBJECTIVE
To determine the efficacy and local tolerance of a new matrix transdermal drug-delivery system that delivers 0.02 mg of 17 beta-estradiol (E2) daily for 7 days for the relief of vasomotor symptoms.
METHODS
A total of 324 surgically or naturally menopausal women, all with prior hysterectomy
Differential Regulation of Gonadotropins in Response to Continuous Infusion of Native Gonadotropin-Releasing Hormone in the Winter Anovulatory Mare and Effects of Treatment With Estradiol-17β.
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We tested the hypotheses that in winter anovulatory mares (1) both chronic daily injections of estradiol-17β (E2) and subcutaneous E2 implants could enhance pituitary secretion of gonadotropins in response to continuous subcutaneous infusion of native gonadotropin-releasing hormone (GnRH); and (2)
Comparative bioequivalence studies with Estradot and Menorest transdermal systems.
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OBJECTIVE
To compare the relative bioavailability of Estradot, a small size, new generation estradiol transdermal system (ETS) to Menorest, in healthy postmenopausal women.
METHODS
In two open-label, single center, randomized, crossover, bioequivalence studies, healthy postmenopausal women aged
Dose proportionality study of four doses of an estradiol transdermal system, Estradot.
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OBJECTIVE
To establish dose proportionality among four doses of a new estradiol transdermal system (ETS), Estradot, in healthy postmenopausal women and to evaluate the wear and irritation properties of the ETS.
METHODS
In an open label, single-dose, randomized, four-period crossover study, healthy
[Pharmacology and metabolism of a new therapeutic drug for prostatic cancer "Estracyt"].
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Estracyt is a new drug for treatment of prostatic cancer, which is a molecule combining estradiol and nornitrogen mustard by a carbamate link. Estracyt is completely dephosphorylated prior to reaching the peripheral circulation after oral administration of the drug to men. Estramustine, i. e.
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