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Page 1 od 28 rezultati
Effect of estrone and estriol on salivary glands and dental caries in female rats.
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The effect of an estrone D-lactam steroid ester derivative on breast cancer cells and its predicted binding interactions with the ligand binding domain of estrogen receptor-alpha.
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In order to further improve the toxicity profile and the anticancer effect of chlorambucil (CBL), we have synthesized a new estrone D-lactam steroidal ester of CBL (ESBL). The aim of this study was to investigate the in vitro activity of ESBL against primary breast carcinoma (BC) cells of operable
[Effect of estrone on formation of the focus of heterotopic hematopoiesis].
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The effect of estrone injections on the heterotopic bone marrow organ formation was studied in (C57Bl X CBA)F1 mice by bone marrow shaft transplantation under the kidney capsule. Estrone injections resulted in femur marrow fibrosis, the increase in the weight of femur and heterotopic organ ossicle,
Effect of oral oleoyl-estrone on adipose tissue composition in male rats.
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OBJECTIVE
To determine whether the oral administration of oleoyl-estrone has similar mass-decreasing effects on the main different sites of white adipose tissue (WAT).
METHODS
Adult male Zucker lean rats were given a daily oral gavage of oleoyl-estrone (OE, 10 micromol/kg) in 0.2 ml of sunflower oil
Structure of human estrone sulfatase suggests functional roles of membrane association.
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Estrone sulfatase (ES; 562 amino acids), one of the key enzymes responsible for maintaining high levels of estrogens in breast tumor cells, is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES, purified from the microsomal fraction of human placentas, has been
Strategies of hemopoietic stress adaptation within the medullary cavity.
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Gravimetric determination of total bone water space was used as an index of available bone marrow space in mice following various specific stressors, i.e., splenectomy, hypoxia, bone fracture, and estrone-induced osteosclerosis. Data was corrected for bone weight and was reported as specific bone
Impaired estrogen production by Leydig cells of the naturally retained testis in unilaterally cryptorchid boars and stallions.
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Estrogen production in vitro was compared for Leydig cells from cryptorchid and scrotal testes in boars and stallions. Animals with natural and experimental cryptorchidism were used. Purified Leydig cells were prepared from testes of mature animals by collagenase treatment and Percoll density
The synthesis of steroids by Taenia crassiceps WFU cysticerci and tapeworms is related to the developmental stages of the parasites.
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Taeniids tapeworms are hermaphroditic helminths that gradually develop testis and ovaries in their reproductive units. The larval stage of the tapeworms named cysticercus is a vesicle that contains the scolex and proliferates asexually in the abdominal cavity of mice. Once in the host, they
Steroid Derived Mesoionic Gold and Silver Mono- and Polymetallic Carbenes.
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A two-step synthesis of gold mesoionic carbene complexes containing estrone moieties has been developed. The method uses the methylation of the triazole nucleus, followed by the treatment of the triazolium salt with Ag2O and transmetalation with [AuCl(SMe2)]. Mono-, bi-, tri-, and tetrametallic gold
Controllable drug uptake and nongenomic response through estrogen-anchored cyclodextrin drug complex.
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Breast cancer is a leading killer of women worldwide. Cyclodextrin-based estrogen receptor-targeting drug-delivery systems represent a promising direction in cancer therapy but have rarely been investigated. To seek new targeting therapies for membrane estrogen receptor-positive breast cancer, an
[Effects of formestane on the skeletal system in ovariectomized and control rates].
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Formestane is an inhibitor of the aromatase enzyme which is uniquely responsible for the generation of estrone and estradiol from androgenic precursors. Formestane is used in the treatment of breast cancer in postmenopausal women. Formestane causes reduction of the estrogen biosynthesis in all
Restricted access property supramolecular solvents for combined microextraction of endocrine disruptors in sediment and sample cleanup prior to their quantification by liquid chromatography-tandem mass spectrometry.
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A supramolecular solvent (SUPRAS) made up of inverted hexagonal aggregates of decanol was here proposed for the simultaneous microextraction of representative estrogenic disruptors (EDs) [viz. estrone (E1), 17β-estradiol (E2), estriol (E3), 17α-ethinylestradiol (EE2) and bisphenol A (BPA)] in
Diagnosis of placental sulfatase deficiency..
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Placental sulfatase deficiency has been found in four pregnancies (cases 1 to 4) with inappropriately low levels of urinary estriol excretion (less than 1.3 mg. per day near term gestation) associated with healthy neonates. The basis of the diagnosis in these cases was the greatly limited capacities
Trauma as a stimulus to marrow regeneration in the osteosclerotic mouse.
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Hemopoietic regeneration was studied in the tibia of mice rendered osteosclerotic by estrone injections. Trauma induced by fracture and periosteal damage was followed by a local hemopoietic response in both normal and osteosclerotic mice. Endosteal damage induced by drilling an artificial cavity in
Ultrasound-induced destruction of low levels of estrogen hormones in aqueous solutions.
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The removal of estrogen hormones from water and wastewater is of importance due to their adverse effects toward ecosystems and potential risks to human health. The ultrasound-induced destruction of estrogen compounds in aqueous solutions is studied in a batch reactor using a 1.1 W/mL sonication unit
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