Medical combination and its method of topical use comprising active ingredients which are sparingly soluble in water, preferably in one single composition against microbes which are pathogenic in humans and animals and which usually appear together. It comprises at least one active ingredient which is effective against several of the opportunally pathogenic strains of the group consisting of fungi Candida, Aspergillus, and/or Fusarium, and aerobic bacteria: Gram-negative bacilli such as Proteus, Pseudomonas, enterobacter species, Escherichia coli, Klebsiella, Serratia marcescens, Citrobacter, Aeromonas; Gram-negative cocci such as Neisseria, Acinetobacter species; Gram-positive bacilli such as Corynebacterium species, Bacillus sphaericus, Gram-positive cocci such as Streptococcus species; anaerobic bacteria: Gram-negative cocci such as Bacteroides, Fusobacteria; Gram-positive cocci such as Peptococcus, Peptostreptococcus species; Gram-positive bacilli such as Clostridium, Propionibacterium, Eubacterium species and Mycobacterium species such as Mycobacterium ulcerans, microbes similar to bacteria of the Chlamydia species such as Chlamydia trachomatis. To be used for treatment of the skin or mucous membranes bearing epithelial lesions, deficiency or injuries and to be used in body cavities to prevent or cure infections and deficiencies. The composition contains-dispersed in a carrier which is pharmaceutically acceptable on the site of treatment-at least one fungicide, which is preferably azole or polyene type and at least one antibacterial compound preferably of the erythromycin, azalide, linkozamide, polypeptide type and at least one bacteriostatic sulphonamide. Additionals mainly for use on skin may include zinc oxide and asulene. Useful in forms of ointment, tablet, effervescent tablet, suppository, foam.

Lukacs; Karoly

Pharmaceutical combinations comprising a fungicide, a bacteriostatic sulphonamide and an antibacterial compound for topical application

The broadest aspect of the invention is a composition and method of treatment of fungal pathologies of the oral cavity or fungal growth on the surface of dentures. A preferred embodiment of the is a pharmacologically effective amount of a peptide selected from the group of peptides with a C-terminal sequence consisting of KPV(SEQ ID NO: 1), HFRWGKPV(SEQ ID NO: 3), and SYSMEHFRWGKPV (SEQ ID NO: 4) in combination with a therapeutically effective amount of a fungicide selected from the group consisting of: itraconazole, econazole, ketoconazole, miconazole, imconazole and fluconazole. Another embodiment of the invention is a method for treating fungal pathologies of the oral cavity and dentures by application of a pharmacologically effective amount of a peptide selected from the group of peptides with a C-terminal sequence consisting of KPV (SEQ ID NO: 1), HFRWGKPV (SEQ ID NO: 3), and SYSMEHFRWGKPV (SEQ ID NO: 4) in combination with a therapeutically effective amount of a fungicide selected from the group consisting of: itraconazole, econazole, ketoconazole, miconazole and fluconazole. In yet another embodiment of the invention these peptides are used in combination with a therapeutically effective amount of gram positive and/or gram negative antibiotics.

Zengen, Inc.

Compounds for treating fungal pathologies of the oral cavity

A device that may be placed on a fingertip for treating an oral cavity. The device may be made from a material comprised of at least one ingredient for treating an oral cavity. Examples of ingredients for treating an oral cavity include abrasives, cavity prevention ingredients, medicinal ingredients (e.g., antiseptics, fungicides, and anesthetics), odor absorbing ingredients, tartar control ingredients, plaque control ingredients, tooth whitening ingredients, ingredients adapted to provide relief from hypersensitivity, and other cleaning ingredients and dentifrices. The device may be dissolvable and edible. Furthermore, some or all of the ingredients may be digestible. For example, the device may be primarily or entirely made of ingredients that are digestible.

fungicide/karijes

Pharmaceutical combinations comprising a fungicide, a bacteriostatic sulphonamide and an antibacterial compound for topical application

Compounds for treating fungal pathologies of the oral cavity

Device and method for treating the oral cavity

Device and method for treating the oral cavity

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