A novel steroid-binding variant of human corticosteroid binding globulin in which one or more of the glycosylation sites, other than the glycosylation site at amino acid position 238, has been functionally disrupted is complexed with an anti-inflammatory ligand in the treatment of inflammation in mammals.

Allelix Biopharmaceutical Inc.

Variants of human corticosteroid binding globulin

Allelix Biopharmaceuticals Inc.

DNA encoding variants of human corticosteroid binding globulin

Bioparyl is obtainable by a disclosed extraction hydrolysis and purification procedure applied to golden autumn leaves of the Gingko biloba tree. Bioparyl plays an important role in the regulation of the activity of certain enzymes, particularly ribonucleases (RNases), implicated in the fundamental mechanism of gene expression. It is low in or free from toxic or side effects in healthy animals, and can be used to ameliorate several pathogenic conditions. Bioparyl is effective in preventing or reversing fibrosis in various tissues, including the lungs and skin, engendered by radiation or chemotherapy. It reduces abnormally high concentrations of gamma-globulins and immuno-globulins found in certain inflammatory or auto-immune diseases, including Acquired Immune Deficiency Syndrome disease (AIDS). In patients with leukemia or solid cancers, Bioparyl normalizes the activity of ribonucleases.

globulin/upala

Variants of human corticosteroid binding globulin

DNA encoding variants of human corticosteroid binding globulin

Bioparyl, a biological regulator, active against various pathologies

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