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Pharmacokinetics and pharmacodynamics of guanidine hydrochloride in an hereditary myasthenia gravis-like disorder in dogs.

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The pharmacokinetic parameters of guanidine hydrochloride were analysed in dogs with an hereditary neuromuscular transmission disorder by the use of 14C-guanidine hydrochloride. The content of intravenously administrated 14C-guanidine hydrochloride in plasma, urine and faeces was determined by

Incidence and risk of fatigue in cancer patients treated with MET inhibitors: A systematic review and meta-analysis.

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The N-methyl-N'-nitroso-guanidine human osteosarcoma transforming gene (MET) inhibitors show a surprising survival benefit in the treatment of numerous tumors especially in MET-high tumor. Besides their impressive efficacy, fatigue reduced by MET inhibitors is still the safety issue

[Pseudo-myasthenic syndromes. Clinical and electromyographic review of 4 cases, one with an unusual reaction to lidocaine (author's transl)].

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The authors report 4 cases of pseudo-myasthenic syndrome followed with EMG for a period varying from a few months to 4 years. They go over the electrophysiological points which led to the diagnosis: small amplitude of the muscle potential evoked by simple shock and, in particular, the phenomenon of

Obstructive sleep apnea presenting as pseudopheochromocytoma.

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A 52-year-old female with a history of poorly controlled resistant hypertension was admitted to our hospital with severe hypertension. She had a history of fatigue and intermittent episodes of palpitations. Laboratory evaluation was significant for elevated 24-h urinary catecholamine levels (3,5

A hereditary neuromuscular disorder in dogs.

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A disorder characterized by reduced tolerance to exercise has been observed in the breed "Gammel Dansk Honsehund." Results of genealogical studies and test matings suggest an autosomal recessive mode of inheritance. Eighteen interrelated dogs were examined electrophysiologically. Recording of

[Thyroid hormone resistance. Clinical, biochemical and genetic study of a family].

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We here present a family where three individuals in three generations had varying degrees of goiter, tachycardia, fatigue, hyperactivity, and learning disability. Serum T3 and free T4 were elevated, whereas TSH was normal or slightly increased. The clinical findings in combination with the hormone

Plasma protein aspartyl damage is increased in hemodialysis patients: studies on causes and consequences.

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Plasma proteins in hemodialysis patients display a significant increase in deamidated/isomerized Asx (asparagine and aspartic acid) content, a marker of protein fatigue damage. This has been linked to the toxic effects of hyperhomocysteinemia in uremic erythrocytes; however, treatment aimed at

Mitochondria disease due to humidifier disinfectants: diagnostic criteria and its evidences

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Humidifier disinfectant damages caused by the misuse of humidifier disinfects, such as polyhexamethylene guanidine (PHMG), resulted in chemical disasters in South Korea in 2011. About four million people were exposed to humidifier disinfectants (HDs) in the 17 years between 1994 and 2011. Although

Myasthenia in patients with dermatomyositis: clinical, electrophysiological and ultrastructural studies.

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In 4 patients with clinical signs of dermatomyositis, confirmed by electromyography and muscle biopsy, a form of muscle fatigue was detected which was expressed clinically by predominantly proximal motor deficit, with phonation and deglutition disturbances, slightly influenced by prostigmine. In all

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