Each patient will undergo mastectomy(ies) if immediate reconstruction is being performed, followed by uni- or bilateral abdominally based free flap harvest, microsurgical anastomoses, and flap inset. If randomized to the ketorolac intervention group, then the participant will receive 30 mg of intravenous (IV) ketorolac tromethamine. The anaesthetist will give participants their first study drug intravenously at the conclusion of surgery. The participant will then continue to receive their assigned drug every 6 hours for 72 hours, for a total of 13 doses. Patients all receive 1:1 care from nursing staff in the early postoperative period, and their nurse will administer all drugs given on the surgical ward.

Each patient will undergo mastectomy(ies) if immediate reconstruction is being performed, followed by uni- or bilateral abdominally based free flap harvest, microsurgical anastomoses, and flap inset. If randomized to the control group the patient will be given a sham IV medication. The sham medication will be normal saline at the same volume as ketorolac, which corresponds to 3 ccs. The anaesthetist will give participants their first study drug intravenously at the conclusion of surgery. The participant will then continue to receive their assigned drug every 6 hours for 72 hours, for a total of 13 doses. Patients all receive 1:1 care from nursing staff in the early postoperative period, and their nurse will administer all drugs given on the surgical ward.

Breast Cancer Female

Ketorolac Tromethamine

Normal Saline

Ketorolac for Analgesia followiNG Autologous Breast RecOnstructiOn

recorded in days beginning post operative day number one

Total narcotic consumption over first 72 hours converted to morphine equivalence

Total surgical drain output over first 72 hours

Any hematoma requiring management in the operating room

Any infection requiring antibiotics, or flap complications requiring management in the operating room

Joey Corkum

Physician

Nova Scotia Health Authority

intravenous methylprednisolone 1 g for three consecutive days at the beginning of months 1, 3 and 5, and oral prednisone 0.5 mg/kg every other day for six months followed by oral prednisone 0.2 mg/kg every other day for a further six months.

intravenous methylprednisolone 1 g for three consecutive days at the beginning of months 1, 3 and 5, and oral prednisone 0.5 mg/kg every other day plus azathioprine 1.5 mg/kg/day for six months followed by oral prednisone 0.2 mg/kg every other day plus azathioprine 50 mg/day for a further six months.

IgA Nephropathy

Chronic Kidney Disease

intravenous methylprednisolone 1 g for three consecutive days at the beginning of months 1, 3 and 5

methylprednisolone

azathioprine 1.5 mg/kg/day for six months followed by azathioprine 50 mg/day for a further six months.

azathioprine

prednisone 0.5 mg/kg every other day followed by prednisone 0.2 mg/kg every other day for a further six months.

prednisone

Steroids and Azathioprine in Advanced IgAN

Steroids and Azathioprine in Early and Advanced IgA Nephropathy: Amendments to a Prospective Randomised Multicenter Trial

time to a 50% increase in serum creatinine from baseline

Claudio Pozzi

A. Manzoni Hospital

Cholecalciferol sachets 120,000 IU monthly for 12 months

Obesity

Insulin Resistance

Oral Cholecalciferol sachets 120,000 IU monthly for 1 year

Cholecalciferol

placebo

Sitaram Bhartia Institute of Science and Research

A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity

A Double Blind Randomized Control Trial to Study the Effect of Long Term Vitamin D Supplementation on Peripheral Insulin Sensitivity in Apparently Healthy Middle Aged Centrally Obese Adults

hematuria/phosphatase

Ketorolac for Analgesia followiNG Autologous Breast RecOnstructiOn

Steroids and Azathioprine in Advanced IgAN

A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity

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