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SELF - BREATHE for Chronic Breathlessness

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STUDY OVERVIEW Full title: A self -guided, internet -based intervention for patients with chronic breathlessness (SELF-BREATHE): an interview study. Objective: To understand the key factors that would enable / facilitate patients with chronic breathlessness to use an online breathlessness support

The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery

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Introduction: Hyperventilation has been used for intraoperative brain relaxation for decades, Interestingly, this common practice is not based on robust evidence . The mechanism of brain relaxation secondary to hyperventilation is attributed to the hypocapnia induced cerebral vasoconstriction and

Hyperventilation and Oxygenation to Prolong Breath Hold in Breast Cancer Irradiation Treatment

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Radiotherapy (RT) has an established role in breast cancer, complementing surgery and systemic therapies to prevent recurrences and improve survival. Long-Term follow-up shows that the beneficial effect on survival is weakened by radiation-induced cardiac and lung cancer mortality, especially in

Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients

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1. Introduction: Chronic Obstructive Pulmonary Disease (COPD) is one of the major causes of chronic morbidity and mortality throughout the world . Many people suffer from the disease for years and die too early from its complications. COPD is the fourth leading cause of death in adults of United

Ultrasound-guided Greater Occipital Nerve Block in Children Undergoing Posterior Fossa Craniotomy

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Surgery within the posterior fossa is associated with the highest incidence and greatest severity of acute postoperative pain that may persist beyond the immediate postoperative period. Despite a greater awareness of pain after all types of intracranial surgery, clinicians remain reluctant to

Assessment of 2 Different Techniques for Suppression of Respiratory Motion in Lung Cancer Treatment With Proton Therapy Using Magnetic Resonance Imaging (MRI)

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Safety of Autologous MSC Infusion to Treat Epilepsy

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The main goal of this phase 1 clinical trial was to evaluate the safety of an autologous mesenchymal stem cell (MSC) application as therapy for drug-resistant symptomatic epilepsy in a one-center study. It is well known that drug-resistant symptomatic epilepsy is a dramatically invalidating disorder

Blood Glucose Concentration & Craniotomy

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METHODS Study Design This prospective observational cohort study, in adult patients who underwent craniotomy for supra or infratentorial surgery as elective or emergency procedure, was approved by the University of Rome "Sapienza", Policlinico Umberto I hospital, Institutional Review Board (2665,

Mechanisms of Exercise-induced Bronchospasm

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At Visit 1, participants will complete questionnaires about demographics, asthma control (if asthmatic) and exercise habits. The participants will have baseline spirometry performed, and skin prick testing for allergies. Skin testing is important as it can influence the level of exhaled nitric oxide

Can Erythropoietin Protect the Cerebral Blood Flow and Oxygenation During Simulated Dive?

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Background During facial cooling and especially during breath hold, can mammals - and also humans - elicit a so called dive reflex, causing bradycardia, peripheral vasoconstriction and centralization of blood flow to brain, lungs and heart (18 Foster et al 2005), but the reflex is suppressed by

Hypertonic Saline 75% vs Mannitol 20%

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Raised intracranial pressure occurs following an expansion of an intracranial mass e.g. hematoma or brain tumor and if left untreated, can lead to brain ischemia, stroke and death. Strategies for reducing raised intracranial pressure include hyperventilation, use of a hyperosmolar agent and the

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