The invention relates to substituted indoles of the formula I
##STR00002## in which R.sup.1 is H, A or SO.sub.2A, A is straight-chain or branched alkyl having from 1 to 10 carbon atoms, alkenyl having from 2 to 10 carbon atoms or alkoxyalkyl having from 2 to 10 carbon atoms, and D-E is
This application is a 371 of PCT/EP03/03806 filed on Apr. 11, 2003.
The invention relates to substituted indoles of the formula I
##STR00002## in which R.sup.1 is H, A or SO.sub.2A, A is straight-chain or branched alkyl having from 1 to 10 carbon atoms, alkenyl having from 2 to 10 carbon atoms or
BACKGROUND ART
Arginine-vasopressin (AVP) is a peptide consisting of 9 amino acids which is synthesized predominantly in the hypothalamus, and is deeply involved as a posterior pituitary hormone in the regulation of blood plasma osmotic pressure, blood pressure and amount of body fluid.
To date,
The invention relates to heterocyclically substituted cycloalkano[b]-indolesulphonamides, to processes for their preparation and to their use in medicaments.
It has already been disclosed that cycloalkano[b]dihydroindole- and -indolesulphonamides have a platelet aggregation-inhibiting action [cf.
BACKGROUND OF THE INVENTION
The present invention relates to novel antagonists of endothelin useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to pharmaceutical methods of
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