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2 rezultati
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
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OBJECTIVE
RNA polymerase I (Pol I)-dependent rRNA synthesis is a determinant factor in ribosome biogenesis and thus cell proliferation. The importance of dysregulated Pol I activity in cardiovascular disease, however, has not been recognized. Here, we tested the hypothesis that specific inhibition
[The Role of DNA Double-strain Damage Repairing Mechanisms in Diabetic Atheroscolersis].
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OBJECTIVE
To identify the role of DNA double-strain damage repairing pathway in the development of diabetics atherosclerosis.
METHODS
Wistar male rats were randomly divided into three groups: control group (group A), balloon injury group (group B) and diabetes + balloon injury group (group C).
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