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Treatment of classic Kaposi sarcoma with a nicotine dermal patch: a phase II clinical trial.

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BACKGROUND Kaposi sarcoma (KS), a malignancy of dermal endothelial cells that is caused by human herpesvirus 8 (HHV8) infection, is sensitive to perturbations of immunity. Nicotine might be effective against KS because of its immunologic and vascular effects and because smoking is associated with a

Soft tissue sarcoma and tobacco use: data from a prospective cohort study of United States veterans.

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A report of an increased risk of soft tissue sarcoma (STS) among users of smokeless tobacco led us to evaluate this association and the role of other types of tobacco in a prospective cohort mortality-study of United States veterans. A total of 248,046 veterans provided tobacco-use histories on a

Muscle sarcomas and alopecia in A/J mice chronically treated with nicotine.

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OBJECTIVE To evaluate the pathobiologic effects of long-term treatment with nicotine of A/J mice susceptible to tobacco-induced lung carcinogenesis. METHODS Experimental group of mice received subcutaneous injections of the LD(50) dose of (-)nicotine hydrogen tartrate of 3 mg/kg/day, 5 days per week

[Mechanism of action of B 518 (endoxan-Asia) jensen sarcoma and inhibition of chemotherapy of tumors by the vitamin nicotine acid amide].

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Studies on the mechanism of translational enhancement by the 5'-leader sequence of tobacco mosaic virus RNA.

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Translation of foreign mRNAs is enhanced by a cis-acting derivative (omega') of the 5'-leader sequence (omega) of tobacco mosaic virus RNA (vulgare strain). To explain this effect we have conducted several experiments in vitro. 1. The presence of various 5'-terminal sequences, including omega', did

Stimulation of the nicotine antiinflammatory pathway improves food intake and body composition in tumor-bearing rats.

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Inflammation contributes to the pathogenesis of cancer anorexia-cachexia syndrome. Nicotine administration reduces cytokine levels and mortality during sepsis. Therefore, nicotine administration may result in improved anorexia-cachexia. Sixteen male Fischer rats inoculated with MCA sarcoma were

Smokeless tobacco extracts modulate exogenous gene expression in early passage cultured human oral epithelial cells: an in vitro system to study chemical and viral enhancer/promoter interaction.

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The increased risk for cancers of the oral cavity from smokeless tobacco use may reflect the interaction of tobacco with genetic factors, such as oncogenes, and other exogenous factors, such as viruses. An in vitro system was developed based on expression of the chloramphenicol acetyltransferase

Age-period-cohort analysis of cancers not related to tobacco, screening, or HIV: sex and race differences.

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OBJECTIVE To identify trends in a residual category of cancers not typically associated with tobacco, screening, or human immunodeficiency virus (HIV) infection. METHODS For persons aged 20-84, we used sex- and race-specific age-period-cohort (APC) models to describe temporal patterns of incidence

Effects of tobacco and tobacco smoke constituents on cell multiplication in vitro.

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Ascites sarcoma BP8 cells, cultured in suspension in vitro were used as a general toxicity test system for tobacco and tobacco smoke constituents. Some 250 compounds, representative of these materials, were examined by exposing cells to different concentrations of these constituents and measuring

Nicotinic receptor and tobacco-related cancer.

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Currently, tobacco smoking causes approximately 5-6 million deaths per year including more than 35% of all cancer deaths. Nicotine, the addictive constituent of tobacco, and its derived carcinogenic nitrosamines, contribute to cancer promotion and progression through the activation of nicotinic

Spindle cell sarcoma of the maxillary antrum.

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Maxillary antral malignancies are mostly squamous cancers. Sarcomas in this region are rare. The head and neck region houses around 8.9% of all sarcomas and spindle cell sarcomas of the maxillary antrum had rarely been reported.The presentation, pathology, clinical findings, management and short

Efficeint transcription of RNA into DNA by avian sarcoma virus polymerase.

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The DNAase digestion end-product of calf thymus DNA contains oligonucleotides that will function as primers for the efficient transcription into DNA of many naturally-occurring RNA's by purified avian sarcoma virus RNA-directed DNA polymerase. The labeled DNA transcripts so obtained are valuable as

Complications after thigh sarcoma resection.

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Standard treatment for extremity sarcoma is limb-sparing surgery often with radiation, but complications occur frequently. We sought to determine factors predictive of wound complications after thigh sarcoma resection and reconstruction while analyzing trends over

Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis.

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There have been conflicting reports of the apoptotic effects of nicotine on human cells and those studies reporting nicotine-induced apoptosis have not unequivocally clarified the molecular mechanisms underlying the effect. However, we found here that human RSa cells, established from embryonic

Properties of a soluble DNA polymerase isolated from Rous sarcoma virus.

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The DNA polymerase of the Prague strain of Rous sarcoma virus of subgroup C and of the Schmidt-Ruppin strain of subgroup A has been solubilized. DNA polymerase purified by sucrose gradient sedimentation and chromatography on DEAE-cellulose represented less than 2% of the soluble [(14)C]protein of

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