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Page 1 od 54 rezultati
Serum activity of ornithine carbamoyl transferase in patients operated with jejunoileal bypass for extreme obesity after pretreatment with aminoacids.
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Increased blood level of the liver specific enzyme ornithine carbamoyl transferase (OCT) is known to be a sensitive indicator of liver cell damage. The effect of preoperative aminoacid infusion to obese patients before jejunoileal bypass due to obesity was studied in 7 patients. They had a
Early changes in the serum activity of ornithine carbamoyl transferase in patients operated on with a jejuno-ileal by-pass for extreme obesity.
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In 13 patients operated on with jejuno-ileal shunting for extreme obesity the serum activity of ornithine-carbamoyl-transferase (S-OCT) was monitored. A rapid rise in the S-COT occurred and was observed at its peak between 2 and 8 hours after the operation. In 4 patients operated on for intestinal
Serum ornithine carbamyltransferase reflects hepatic damage in diabetic obese mice.
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OBJECTIVE
As ornithine carbamyltransferase (OCT) has proved to be a sensitive serum marker in the detection of hepatotoxicity in several models, it is important to confirm its application to the diagnosis of non-alcoholic fatty liver disease.
METHODS
C57BL/6, KK-Ta and KK-Ay mice were fed a high-fat
[Effect of ornithine oxoglutarate on the duration and quality of wound healing in extensive reparative and plastic surgical methods].
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Fifty-two overweight female patients hospitalized for a major plastic surgical procedure were included in a therapeutic trial designed to evaluate wound healing. Twenty-seven patients were randomized to a placebo and 25 to ornithine oxoglutarate (Cetornan). There were no statistical differences
Altered plasma free amino acid levels in obese traumatized man.
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Obesity is a major nutritional disorder that produces many abnormal metabolic responses. The effect of injury-induced stresses acting synergistically with the state of excessive body fat is not well known. Plasma levels of circulating free amino acids reflect the net status of protein breakdown and
Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome.
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In humans, plasma amino acid concentrations of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) increase in states of obesity, insulin resistance and diabetes. We here assessed whether these putative biomarkers can also be identified in two different obesity and diabetic mouse
Mass Spectrometry-Based Metabolomic and Lipidomic Analyses of the Effects of Dietary Platycodon grandiflorum on Liver and Serum of Obese Mice under a High-Fat Diet.
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We aimed to identify metabolites involved in the anti-obesity effects of Platycodon grandiflorum (PG) in high-fat diet (HFD)-fed mice using mass spectrometry (MS)-based metabolomic techniques. C57BL/6J mice were divided into four groups: normal diet (ND)-fed mice, HFD-fed mice, HFD with 1% PG
Adaptation in enzyme (metabolic) pathways to obesity, carbohydrate diet and to the occurrence of NIDDM in male and female SHR/N-cp rats.
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Twenty-four male (12 obese and 12 lean) and 21 female (11 obese and 10 lean) SHR/N-cp rats were fed a diet containing either 54% sucrose or starch for periods of 3-4 months. Rats were killed after a 14-16 h fast and liver enzyme activities were determined in both sex groups. Liver
Infusion of ornithine-alpha-ketoglutarate in healthy subjects: effects on protein metabolism.
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Infusion of ornithine-alpha-ketoglutarate (Ornicetil) has been suggested to improve nitrogen balance in trauma patients. Whether this anticatabolic effect is localised to the liver or to skeletal muscle is as yet unknown. Consequently, the splanchnic and leg exchange of amino acids, urea and ammonia
Metabolic and hormonal factors as predictors of nitrogen retention in obese men consuming very low calorie diets.
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The ability to conserve body protein during very low calorie diets in ten obese men was observed to correlate with plasma free amino acid concentrations, urinary N tau-methylhistidine: creatinine ratios, resting oxygen consumption, and serum triiodothyronine levels. A diet consisting of only
Microarray analysis of obese women with polycystic ovary syndrome for key gene screening, key pathway identification and drug prediction.
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OBJECTIVE
This study aimed to screen key genes and pathways involved in obese polycystic ovary syndrome (PCOS), and predict drugs for treatment of obese PCOS via bioinformatics approaches.
METHODS
Microarray dataset GSE10946 were downloaded from the Gene Expression Omnibus database, including 7
Energy expenditure and substrate oxidation rates of obese rats during a 12-day treatment with dexfenfluramine.
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Serotoninergic neuronal networks are included in regulation and modification of eating behavior and energy metabolism. Dexfenfluramine (dF), a serotonin releaser and reuptake inhibitor, was used to investigate changes in food intake, body weight development, energy expenditure, respiratory quotient,
An oral amino acid loading test before and after intestinal bypass operation for morbid obesity.
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Blood samples were taken from six overweight women after an overnight fast on three different occasions, before an jejunoileal bypass operation and 1 and 6 months after the operation. The preoperative levels of several plasma free amino acids were significantly elevated, e.g. leucine, isoleucine,
Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women.
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What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome?
A randomised crossover trial with 15 healthy obese men and women (age 24-70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of
Antiglucocorticoid action of dehydroepiandrosterone in young obese Zucker rats.
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Dehydroepiandrosterone (DHEA) reduces weight gain in the hypercorticosteronemic Zucker fatty rat, an animal model of genetic obesity. However, the mechanism of action of DHEA is still unclear. We propose that DHEA acts as an antiglucocorticoid in the Zucker fatty rat. To test this hypothesis we
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