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osteoporosis/fever

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Corticotropin releasing factor antagonists

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BACKGROUND OF THE INVENTION The present invention relates to the treatment of certain conditions using a compound of formula I or II, or a pharmaceutically acceptable salt thereof, as defined below. Specifically, the compounds of formulas I and II, and their pharmaceutically acceptable salts, as
FIELD OF THE INVENTION The present invention relates to the preparation of an enriched and equilibrated plant extract from Solanum glaucophyllum with an enriched content of 1,25-dihydroxyvitamin D.sub.3 glycosides and flavonols, particularly quercetin glycosides. The present invention particularly
The present invention relates to the preparation of an enriched and equilibrated plant extract from Solanum glaucophyllum with an enriched content of 1,25-dihydroxyvitamin D.sub.3 glycosides and flavonols, particularly quercetin glycosides. The present invention particularly describes a method for

Pyrimidine compounds and their uses

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FIELD Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. ##STR00002## The present invention also

Pyrimidine compounds and their uses

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FIELD Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. ##STR00002## The present invention also

Heterocycles

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FIELD Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly

Substituted heterocyclic compounds and methods of use

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BACKGROUND OF THE INVENTION The present invention comprises a new class of compounds useful in treating diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the

Substituted heterocyclic compounds and methods of use

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BACKGROUND OF THE INVENTION The present invention comprises a new class of compounds useful in treating diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the

Pyrimidine carboxamides

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FIELD OF THE INVENTION The present invention relates to novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their

Substituted heterocyclic compounds and methods of use

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BACKGROUND OF THE INVENTION The present invention comprises a new class of compounds useful in treating diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the

Substituted heterocyclic compounds and methods of use

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BACKGROUND OF THE INVENTION The present invention comprises a new class of compounds useful in treating diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the

Substituted heterocyclic compounds and methods of use

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BACKGROUND OF THE INVENTION The present invention comprises a new class of compounds useful in treating diseases, such as TNF-.alpha., IL-1.beta., IL-6 and/or IL-8 mediated diseases and other maladies, such as pain and diabetes. In particular, the compounds of the invention are useful for the

Synthesis of 1.alpha.,25-dihydroxy-24R-fluorocholecalciferol and 1.alpha.,25-dihydroxy-24S-fluorocholecalciferol

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BACKGROUND OF THE INVENTION This invention relates to 24R- and 24S-fluoro analogs of 1.alpha.,25-dihydroxycholecalciferol. Vitamin D.sub.3 is a well-known agent for the control of calcium and phosphorous homeostasis. In the normal animal or human this compound is known to stimulate intestinal
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