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Quality of Protein From the Common Bean

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Humans require certain minimal quantities of the indispensable amino acids (IAA) from dietary proteins to maintain healthy growth and body function (1). These amino acids are not made in the body and must be provided in the diet. Protein quality is about how dietary proteins can satisfy the body's

IL-6 Regulation of Substrate Metabolism and Influence of Obesity

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The aim of the study is to assess changes in substrate kinetics, that is, lipolytic rate, rate of appearance and disappearance of free fatty acids, fatty acid oxidation, glucose rate of appearance and disappearance and protein synthesis and degradation during rest and exercise with and without IL-6

Effect of the Quality of Dietary Proteins on the Sleep Young Elite Athletes and the Obese Adolescent

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Double-blind controlled pre-post trial where each subject acts as his own control. Three measurement sessions will be performed for each teenager. Each session will be conducted over a week. Each teenager will participate in three protein enrichment sessions: PROT1 session, PROT2 session, and

Nutritional Status in Phenylketonuria

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At the Centro Hospitalar do Porto (Reference Centre for the treatment of Inherited Metabolic Diseases) the annual nutritional status evaluation routinely generates data on anthropometry, body composition, blood pressure, nutritional intake and clinical biochemistry. Since 2009, all this information

Determining the Muscle Anabolic Properties of Phosphatidic Acid.

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The investigators will recruit 16 healthy (non-obese, non-diabetic, non-smokers) elderly men aged 65-80 yrs to complete a double-blinded, parallel designed study, in which they will be randomly assigned to a phosphatidic acid (N= 8; PA) or placebo (N=8; PL) treatment group, matched closely for

Resistance Exercise and Muscle Protein Synthesis in Obese Adults

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Baseline procedures: A parallel group design will be used for this study. Prior to the infusion trial, participants will reported to the laboratory on two separate occasions in the morning. On the first visit, we will determine participants' body weight and height as well as body composition by

Can Supplemental Leucine Offset Disuse-induced Muscle Atrophy?

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It is well established that skeletal muscle mass progressively declines with healthy ageing, a phenomenon commonly termed sarcopenia. Overtime, this leads to a loss in functional independence and provides an increased risk of developing a co-morbidity. Recent estimates suggest that 30% of those aged

Muscle Protein Synthesis Rates After Protein Consumption in Lean, Overweight, and Obese Adults

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Participants will be asked to report to the laboratory at 7:00 am following an overnight fast. Upon arrival, a Teflon catheter will be inserted in an antecubital vein of one arm for arterialized blood sampling and a baseline blood sample will be drawn. Arterialized blood samples will be obtained by

Impact of Phenylketonuria-type Diet on Appetite, Appetite Hormones and Diet Induced Thermogenesis

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Effect of Obesity-derived Cytokines on Protein Turnover and Carbohydrate Metabolism in Human Skeletal Muscle

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Recruitment of subjects: 24 obese (but otherwise healthy) participants with elevated cytokine levels and 24 non-obese subjects with normal cytokine levels will be recruited. Following the first experimental visit (see below), participants will be divided in a double-blind fashion into four groups

Association of Kisspeptin Levels With Insulin Secretion in Diabetes Mellitus

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INTRODUCTION: Since the discovery of kisspeptin as a "gate-keeper" of hypothalamo-pituitary-gonadal axis, there has been tremendous interest in the molecule. Kisspeptins are a group of peptides derived from the kiss gene, which share a common C-terminal decapeptide with an arginine-phenylalanine

Impact of Carbohydrate Co-ingestion on the Post-prandial Anabolic Response of Protein in Young and Elderly Men

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With human aging, there is a gradual but progressive decline in skeletal muscle tissue, also known as sarcopenia . Sarcopenia is accompanied by a reduced physical performance, the loss of functional capacity, increased risk of falling and increased likelihood of developing chronic metabolic

Impact on the Proteolysis of Obesity in Dialysis

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In hemodialysis patients, the risk of death decreases almost linearly as BMI increases, including in obese patients. Experimental data suggest that obesity may be associated with a reduction of muscle proteolysis during fasting. In the hemodialysis patients, after an overnight fast an increased use

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