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phenylalanine/seizures
Veza se sprema u međuspremnik
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Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats.
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The critical role of α1-glycine receptor (α1-GLYRs) in pathological conditions such as epilepsy is well known. In the present study, structure-activity relations for a series of phenylalanine derivatives carrying selected hydrogen bond acceptors were investigated on the functional properties of
Pharmacological effects of phenylalanine on seizure susceptibility: an overview.
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The effects of excessive doses of phenylalanine on seizure susceptibility were examined in animal models in the past, primarily because of their relevance to phenylketonuria. It was thought that such effects might involve brain monoaminergic mechanisms. Recently, this issue has been pursued with a
AUDIOGENIC SEIZURES, THE DILITE LOCUS, AND PHENYLALANINE HYDROXYLASE IN DBA/1 MICE.
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Reduced audiogenic seizure susceptibility in dilute mice was associated with enhancement of phenylalanine hydroxylase activity, previously reported as low in dilute mice. Though nutritional changes complicate the interpretation, evidence exists for a mutation linked with dilute which modifies
Effects of phenylalanine and 5-hydroxytryptophan on seizure severity in mice.
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The degree of audiogenic seizure was measured in DBA/2J (phenylalanine hydroxylase deficient) mice as a function of dietary phenylalanine (Phe) and injected 5-hydroxytryptophan (5-HTP), the precursor of serotonin (5-HT). Phe was shown to exacerbate seizures significantly, and seizure severity was
Effect of tyrosine on the potentiation by aspartame and phenylalanine of metrazol-induced convulsions in rats.
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Male rats were treated by oral intubation with tyrosine (Tyr), at doses of 0.5 and 1.0 g/kg body weight, alone or together with 1 g aspartame (APM)/kg body weight, or an equivalent dose of phenylalanine (Phe; 0.5 g/kg body weight); the effects on seizures induced by an effective dose of metrazol
Aspartame and phenylalanine do not enhance theophylline-induced seizures in rats.
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Oral administration of the artificial sweetener aspartame, 1 g/kg, or of an equimolar dose of its metabolite phenylalanine, to fasted rats 1 hour before slow i.v. infusion of theophylline until the onset of maximal seizures had no significant effect on the total dose and the serum and cerebrospinal
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
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OBJECTIVE
Abnormal glutamatergic activity is implicated in neurologic and neuropsychiatric disorders. Selective glutamate receptor antagonists were highly effective in animal models of stroke and seizures but failed in further clinical development because of serious side effects, including an almost
Additive effect of 5-hydroxytryptophan and p-chloro-phenylalanine in preventing audiogenic seizures in inbred mice.
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Convulsive responsiveness of O'Grady mice, inbred for susceptibility to audiogenic seizures, was decreased following treatment with the serotonin precursor, 5-hydroxytryptophan, or serotonin depletor, p-chlorophenylalanine. Neither agent exerted any antagonistic or synergistic action on the effect
Relationship of phenylalanine to seizure threshold during maturation.
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The relationships between phenylalanine, phenylpyruvate, vitamin B-6 and seizure threshold.
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[Neuropsychiatric study on the effects of low-phenylalanine diet in phenylketonuria. 1. Electroencephalography, convulsions, developmental index and associated personality changes with low-phenylalanine diet therapy for phenylketonuria].
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[Successful dietetic treatment of phenylketonuria using "phenylalanine-poor protein hydrolysate Berlin-Chemie". 2. EEG findings and convulsions].
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Altered amino acid levels in multiply affected sibships with seizures.
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Evidence of genetic factors in seizure disorders by examination of plasma amino acid concentrations in multiply affected sibships was investigated. The strategy of multiply affected sibship ascertainment was used to reduce heterogeneity as one of several potential sources of variation in
Influence of pharmacological manipulation of inhibitory and excitatory neurotransmitter systems on seizure behavior in the Mongolian gerbil.
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The purpose of this paper was to study the relationship between different neurotransmitter systems and seizure susceptibility in Mongolian gerbils with genetically determined epilepsy. In these animals, generalized tonic-clonic seizures were induced by stimulation with a blast of compressed air. A
Lack of effect of aspartame or of L-phenylalanine on photically induced myoclonus in the baboon, Papio papio.
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The effects of large doses of L-phenylalanine and of aspartame on seizure susceptibility and severity have been assessed in baboons Papio papio from Senegal which show photosensitive epileptic responses similar to primary generalised epilepsy in man. L-Phenylalanine, 50, 150 or 450 mg/kg, or
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