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The lung is the major site expressing plasma phospholipid transfer protein (PLTP) mRNA in humans and mice, suggesting that this protein might have an important role in maintaining normal function of this organ. In the lung of human collagenase transgenic mice, an emphysematous animal model, PLTP
There is evidence that dietary polyunsaturated fatty acids (PUFA) may protect against cardiovascular diseases, but the involvement of the cardiac muscle cell in this beneficial action remain largely unknown. The present study compared the respective influence of n-3 and n-6 PUFA on the function of
The influence of membrane polyunsaturated fatty acid (PUFA) composition on lactate production, energy status, enzyme leakage and cell defences against oxygen free radical production was studied in cultured rat ventricular myocytes during hypoxia and reoxygenation. After 4 days in a conventional
Tissue-dependent alterations in composition of phospholipids, studied by means of thin-layer chromatography, were detected in plasma, microsomal and mitochondrial membranes of rat brain and liver tissues after influence of acute hypoxia in the altitude chamber at a "height" of 12,000 m 3-9 min.
Adult male Wistar rats were exposed to intermittent high altitude hypoxia of 7000 m simulated in a hypobaric chamber for 8 h/day, 5 days a week; the total number of exposures was 25. The concentration of individual phospholipids and their fatty acid (FA) profile was determined in right (RV) and left
The content and the intensity of metabolism of various phospholipid groups (phosphatidylcholines, monophosphoinositides, aminophospholipids) was studied in the homogenate, microsomes, and cytozol of the rat brain under normal conditions and in hypoxic hypoxia (240 mm Hg). Phospholipid content per 1
After acute hypoxia (3 hrs, P-200 mm Hg) content of total phospholipids and of their fractions was not altered in rat lung parenchyma, but the phospholipid composition, changed due to preadministration of hydrocortisone or insulin, was normalized. After the hypoxia concentration of phospholipids in
Changes in the composition and contents of phospholipids and free fatty acids were observed and compared in three groups: (A) unpreconditoned normal controls, (B) exposure to 1 run of hypoxia and (C) exposure to 4 runs of hypoxia. In group B, the content of phosphatidyl ethanolamine (PE),
The effect of maternal treatment with dexamethasone on blood PO2, PCO2, pH and lactate concentrations and on lung phospholipid content in premature newborn rats during the early neonatal period was studied. The postnatal hypoxia shown by premature newborn rats was prevented by this treatment.
Multiple pathologic conditions, including hemorrhage, tumor angiogenesis, and ischemia-reperfusion events, will result in hypoxia and subsequent reperfusion. Previous studies have analyzed the lipid changes within whole tissues and indicated that ischemia-reperfusion altered tissue and cellular
We have previously reported alterations in cyclooxygenase metabolism in cultured aortic and pulmonary arterial endothelial cells exposed to acute and chronic hypoxia. These alterations depended on the duration and degree of the hypoxic exposure, on the vascular bed from which the endothelial cells
The phsopholipid composition of lung tissue and lung lavage in rats exposed to acute hypoxia, chronic hypoxia, and acute and chronic hypoxia associated with cold has been estimated and compared with controls. Different fractions of phospholipids were separated by thin layer chromatography. Results
BACKGROUND
Prenatal hypoxia is an important cause of intrauterine growth retardation that affects fetal lung maturation, although previous studies have rendered conflicting results. The fetal chicken model allows the study of the isolated effects of hypoxia during development.
OBJECTIVE
We
We have studied, in the rat, the action of a vaporization with sulphurous water from Bagnères de Luchon on the surfactant modifications caused by hypoxia. The phospholipase activity, subordinate to hypoxia, decreased by 1/5 compared to its value without treatment and the phospholipid composition of
The development of autolysis in grey brain matter of albino rats was accompanied by desintegration of aminophospholipids with parallel increase of glycerophosphates (GLP) and phosphatidic acids (PA) on early stages of incubation and lysophospholipids (LPL) on later stages. Acute hypobaric hypoxic