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3 rezultati
Open-label, clinical phase I studies of tasquinimod in patients with castration-resistant prostate cancer.
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BACKGROUND
Tasquinimod is a quinoline-3-carboxamide derivative with anti-angiogenic activity. Two open-label phase I clinical trials in patients were conducted to evaluate the safety and tolerability of tasquinimod, with additional pharmacokinetic and efficacy assessments.
METHODS
Patients with
EORTC phase II study of daily oral linomide in metastatic renal cell carcinoma patients with good prognostic factors.
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Following a previous EORTC GU-Group study, in which linomide showed some activity in poor prognosis patients, this study was initiated to determine the effect of linomide in more favourable patients. 35 patients with metastatic renal cell carcinoma with good prognostic factors, i.e. good performance
Efficacy of tasquinimod in men with metastatic castration-resistant prostate cancer: A meta-analysis of randomized controlled trials.
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BACKGROUND
Tasquinimod is an oral quinoline-3-carboxamide derivative for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Tasquinimod has antiangiogenic, immunomodulatory, and antimetastatic properties, but it is also associated with toxicities, including skeletal pain,
Najkompletnija baza ljekovitog bilja potpomognuta naukom
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