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Page 1 od 104 rezultati
Active pharmaceutical ingredients and mechanisms underlying phasic myometrial contractions stimulated with the saponin extract from Paris polyphylla Sm. var. yunnanensis used for abnormal uterine bleeding.
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BACKGROUND
Total steroidal saponins of Paris polyphylla Sm. var. yunnanensis (TSSP) have been widely used in China for the treatment of abnormal uterine bleeding (AUB). But until now, the main active constituents and the mechanisms underlying the pharmacological actions on uterine activity have not
[Effect of panax notoginseng saponins injection on brain edema in intracerebral hemorrhage rats].
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OBJECTIVE
To study the effect of panax notoginseng saponins (PNS) in treating hemorrhagic apoplexy at super-early stage in rats.
METHODS
Rat model of hypertension with cerebral hemorrhage was induced by collagenase method. Sixty rats were randomly divided into 5 groups: the sham operated group,
Protective mechanism of Panax notoginseng saponins on rat hemorrhagic shock model in recovery stage.
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To explore protective mechanism of Panax notoginseng saponins (PNS) on rat hemorrhagic shock model in recovery stage. 72 Wistar rats were selected and divided into control group, model group and PNS group with 24 rats in each group. 200 mg/kg PNS was injected intravenously at 60 min of hemorrhagic
Neuroprotective Effect of Radix Trichosanthis Saponins on Subarachnoid Hemorrhage.
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Redox homeostasis has been implicated in subarachnoid hemorrhage (SAH). As a result, antioxidants and/or free radical scavengers have become an important therapeutic modality. Considering that radix trichosanthis (RT) saponins exhibited strong antioxidant ability both in vivo and in vitro, the
A new semisynthetic ocotillol-type saponin and resuscitation of haemorrhagic shock.
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A new ocotillol-type saponin (PGQ) has been semisynthesised from 20(S)-ginsenoside Rg3 for the first time, in with a yield of 73%, by oxidation and cyclisation of the side-chain. Its structure was characterised by IR, HR-MS, (1)H NMR, (13)C NMR, (1)H-(1)H COSY, DEPT, HMBC and HMQC spectroscopy as
[Effect of Panax notoginseng saponins on serum neuronal specific enolase and rehabilitation in patients with cerebral hemorrhage].
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OBJECTIVE
To observe the effect of Panax notoginseng saponins (PNS) on serum content of neuronal specific enolase (NSE) and function recovery in patients with cerebral hemorrhage (CH) for exploring the therapeutic action of PNS in treating CH.
METHODS
Fifty CH patients with their course of disease
Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action.
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Intracranial/intracerebral hemorrhage (ICH) is a leading cause of death and disability in people with traumatic brain injury (TBI) and stroke. No proven drug is available for ICH. Panax notoginseng (total saponin extraction, PNS) is one of the most valuable herb medicines for stroke and
[Effect of blood loss and acute saponin experiments on myelopoisis in rabbits].
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[Effects of Panax notoginseng saponins on hemorrhagic shock in rabbits].
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Optimization of fixed-permeabilized cell monolayers for high throughput micro-neutralizing antibody assays: application to the zebrafish/viral hemorrhagic septicemia virus (vhsv) model.
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A new high throughput centrifugation-free method to estimate viral neutralizing antibody levels in low volumes and large numbers of plasma blood samples is described. Cell monolayers were, (i) plated on poly-d-Lys coated 96-wells, (ii) infected with viruses previously incubated with fish plasma
Effects on chicks of Balanites aegyptiaca kernel saponin given by different routes of administration.
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The effect of oral or parenteral administration of crude saponin extract from Balanites aegyptiaca seed kernal on Hisex-type chicks was studied. Seven-d-old chicks were given 5 mg Balanites crude saponin/kg/d im, 25 mg/kg/d ip or 250 mg/kg/day po for 3 w. When compared to controls, the body weights
Investigation into the anti-thrombosis effect and contents of total saponins and flavonoids in the bioactive fraction of Naodesheng prescription.
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BACKGROUND
Naodesheng prescription is a widely used traditional Chinese medicine (TCM), and mainly applied in clinics to treat cerebral arteriosclerosis, ischemic stroke, sequelae of cerebral hemorrhage etc.
OBJECTIVE
The present study was designed to investigate the anti-thrombosis effects of this
Effects of endothelium removal by saponin and of oxyhemoglobin on canine cerebrovascular responses.
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The stainless steel cannula method was applied to isolated and perfused canine basilar arteries to examine the role of endothelium in the responses to intraluminal vasoactive substances. After intraluminal treatment with saponin to remove the endothelium, the monophasic constrictions to potassium
Constituents and Antioxidant Activity of Bleeding Sap from Various Xinjiang Grapes.
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UNASSIGNED
Wine grape sap or bleeding sap of grapes (GBS) is commonly used in Xinjiang (China) for therapeutic aims. Do variations in composition related to region and variety affect its properties?
UNASSIGNED
GBS samples originating in various parts of Xinjiang (Turpan, Hotan, Kashgar, and Atush)
Triterpenoid saponins, new metalloprotease snake venom inhibitors isolated from Pentaclethra macroloba.
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We report here the antiproteolytic and antihemorrhagic properties of triterpenoid saponin inhibitors, named macrolobin-A and B, from Pentaclethra macroloba, against Bothrops snake venoms. The inhibitors were able to neutralize the hemorrhagic, fibrin(ogen)olytic, and proteolytic activities of class
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