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Aspirin aggravates the degeneration of canine joint cartilage caused by immobilization.

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The effect of aspirin on the degeneration of knee cartilage caused by immobilization was examined. If dogs were fed aspirin daily (serum salicylate = 20-25 mg/dl) for 6 weeks while one hind limb was immobilized in a cast, the decreases in uronic acid content and net proteoglycan synthesis in

Effects of tiaprofenic acid on the concentration and metabolism of proteoglycans in normal and degenerating canine articular cartilage.

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The effects of tiaprofenic acid (TPA), a nonsteroidal antiinflammatory drug with high potency as a cyclooxygenase inhibitor, on the metabolism of normal and degenerating articular cartilage were examined. When present in the culture medium in clinically relevant concentrations encompassing those

Relative increase of biglycan and decorin and altered chondroitin sulfate epitopes in the degenerating human intervertebral disc.

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OBJECTIVE Proteoglycans are major components of the extracellular matrix of the intervertebral disc. They are vital for the biomechanical properties of the tissue, and are subject to changes in disc degeneration. We aimed to further define these changes and their relationship to normal

Effects of tiaprofenic acid and indomethacin on proteoglycans in the degenerating porcine intervertebral disc.

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METHODS Eighteen pigs were stabbed with a scalpel in the anterior part of the anulus fibrosus of a lumbar disc. After surgery, the pigs received either tiaprofenic acid or indomethacin daily, and a third group did not receive any medication. OBJECTIVE Nonsteroidal anti-inflammatory agents are widely

The degradation of glycosaminoglycans by intestinal microflora deteriorates colitis in mice.

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The biosynthesis and modification of mucopolysaccharides and glycosaminoglycans (GAGs), secreted from gastrointestinal mucosal cells, are increased in colitis and influence the viability of the defense barrier. Therefore, to evaluate the role of GAG-degrading intestinal microflora during the

Experimental intervertebral disc degeneration: morphologic and proteoglycan changes over time.

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An animal model of intervertebral disc degeneration produced by surgical ventral disc herniation in the rabbit is described. Histologic studies showed proliferation of cells on the inner third of the annular wound, with metaplasia into fibrocartilage in the first 2 weeks following injury.

Effects of Crude Fucus distichus Subspecies evanescens Fucoidan Extract on Retinal Pigment Epithelium Cells-Implications for Use in Age-Related Macular Degeneration.

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Fucoidan extracts may have beneficial effects in age-related macular degeneration(AMD). Over-the-counter fucoidan preparations are generally undefined, crude extracts. In thisstudy, we investigated the effect of a crude fucoidan extract from Fucus distichus subspeciesevanescens (Fe) on the

The effects of postoperative joint immobilization on articular cartilage degeneration following meniscectomy.

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Bilateral medial meniscectomy was performed in 12 mature greyhounds. One knee joint of half the group was immobilized by a Kirschner splint for a period of 5 weeks immediately following meniscectomy, after which the device was removed and the animals were allowed free movement for a further 21 weeks

Construction and characterization of a Pseudomonas aeruginosa mucoid exopolysaccharide-alginate conjugate vaccine.

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Deterioration of lung function in patients with cystic fibrosis (CF) is closely associated with chronic pulmonary infection with mucoid Pseudomonas aeruginosa. The mucoid exopolysaccharide (MEP) from P. aeruginosa has been shown to induce opsonic antibodies in mice that are protective against this

[Response of the joint tissues to the presence of a foreign body implanted into the rabbit knee. A new model of experimental arthrosis].

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The joint tissues (synovium, articular cartilage and bone), respond rapidly and consistently to the presence of a piece of polypropylene surgically implanted into the Rabbit knee joint. In the contact of a foreign body, a synovium proliferates in an attempt to isolate and exclude the intruder from

Lentiviral-mediated gene therapy for murine mucopolysaccharidosis type IIIA.

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Mucopolysaccharidosis type IIIA (MPS IIIA) is a heritable glycosaminoglycan (GAG) storage disorder which is characterised by lysosomal accumulation of heparan sulphate, secondary to a deficiency of sulphamidase (heparan-N-sulphatase, N-sulphoglucosamine sulphohydrolase, EC No. 3.10.1.1.). There is

Sucrose has no beneficial effects on wound healing in rats.

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OBJECTIVE To evaluate the effects of sucrose treatment on the formation of granulation tissue in a standard wound model. METHODS Animal study. METHODS University hospital, Finland. METHODS 32 male Sprague-Dawley rats divided into 4 groups. METHODS Implantation of viscose cellulose sponge

Glycosaminoglycans in patellar cartilage.

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We obtained samples of patellar cartilage at the time of surgery from 20 patients: 11 with normal and 9 with macroscopic cartilaginous degeneration. The glycosaminoglycans were separated by cellulose acetate electrophoresis, and the relative content of major glycosaminoglycans was measured by optic

[Studies on physico-chemical properties and hypoglycemic activity of complex polysaccharide AMP-B from Atractylodes macrocephala Koidz].

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OBJECTIVE To isolate a complex polysaccharide (AMP-B) from Atractylodes macrocephala Koidz and study its phtsico-chemical properties and hypoglycemic activity. METHODS The root of Atractylodes macrocephala K. was extracted with water and precipitated with ethanol, dialyzed against water and

Local panatrophy with linear distribution: a clinical, ultrastructural and biochemical study.

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A young female with local panatrophy of the right-side extremities affecting all mesodermal layers--dermis, subcutaneous tissue, muscles, and bone--is described. The atrophies were strictly linear. Ultrastructurally, collagen fibrils of the reticular dermis from the atrophic area consisted of two

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