Life Sciences 2014-Nov
Engineered heart tissue transplantation alters electrical-conduction function in rats with myocardial infarction.
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OBJECTIVE
To investigate how affects electrical-conduction function following myocardial infarction (MI) in rats.
METHODS
Thirty SD rats of either sex (220-250 g) were anesthetized using chlorine hydrate and were randomly divided into three groups: control group, MI group and transplantation group. The field potential (FP) morphology and activation-conduction duration were recorded with microeletrode array techniques.
RESULTS
The MEA recorded clear FP morphology. Activation-conduction duration was (6.5 ± 2.12) ms in the control group, (17.5 ± 3.54) ms in the MI group, and (9.13 ± 1.31) ms in the transplantation group.
CONCLUSIONS
EHT transplantation can improve electrical-conduction and function of MI rats.
