[Tobacco and alcohol are risk factors of complicated peptic ulcers. A prospective cohort study].

Both the incidence of and mortality from bleeding and perforated peptic ulcers are growing. We assessed the association between smoking, ingestion of alcohol (including the type of alcoholic beverage), and risk of a complicated peptic ulcer in a population-based study of 26,518 Danish subjects followed up for an average of 13.4 years. There were 214 cases of incident bleeding and 107 cases with perforated ulcers. We estimated the relative risks (RRs) of incident bleeding and perforated peptic ulcers with the Poisson regression analysis. Smoking more than 15 cigarettes a day compared with never smoking increased the risk of a perforated ulcer more than threefold (RR = 3.5; 95% confidence interval [CI] = 1.7-7.1). Ingestion of more than 42 drinks a week increased the risk of a bleeding ulcer fourfold (RR = 4.4; 95% CI = 2.3-8.3) compared with ingestion of less than one drink a week. Comparison of the same group, showed that subjects who ingested more than 21 drinks a week, but no wine, were at a higher risk of a bleeding ulcer (RR = 8.8; 95% CI = 2.2-35) than drinkers of the same amount of alcohol, but with more than 25% of their intake as wine (RR = 2.4; 95% CI = 1.0-6.0).