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Pàgina 1 des de 182 resultats
N-acetylcysteine amide (NACA) prevents retinal degeneration by up-regulating reduced glutathione production and reversing lipid peroxidation.
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Oxidative stress plays a critical role in accelerating retinal pigment epithelial dysfunction and death in degenerative retinal diseases, including age-related macular degeneration. Given the key role of oxidative stress-induced retinal pigment epithelial cell death and secondary photoreceptor loss
Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration.
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Repair of degenerated intervertebral discs (IVD) might be established via intradiscal delivery of biologic therapies. Polyester amide polymers (PEA) were evaluated for in vitro cytotoxicity and in vivo biocompatibility, and thereafter intradiscal application of PEA microspheres (PEAMs) in a canine
[On the biochemistry of testicular atrophy caused by unilateral experimental cryptorchism. Enzyme kinetic studies on the leucine amide-splitting peptidase of the normal and atrophic rat testis].
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[Data on the intensity of N-15 incorporation into the amide group of skeletal muscle glutamine in atrophy of varied origin].
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Separation of NOEs from degenerate amide protons in 13C/15N-labeled proteins using a 3D 13C'-edited NOESY-H(N)CO experiment.
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Construction and conformational behavior of peptoids with cis-amide bond geometry: design of a peptoid with alternate φ, ψ values of inverse PP-II/PP-II and PP-I structures.
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In peptoids due to the absence of amide protons, the backbone is devoid of hydrogen bond donor, linked by tertiary amide, which can be iso-energetic between cis and trans-amide bond geometry. The peptoids can be realized with cis amide bond if the side chain of ith residue can engage the carbonyl
Deterioration Mechanism of a Tertiary Polyamide Reverse Osmosis Membrane by Hypochlorite.
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A tertiary polyamide membrane was synthesized using N,N'-dimethyl-m-phenylenediamine. The durability of this membrane to chlorination by hypochlorite treatment followed by sodium hydroxide treatment was examined, and then deterioration mechanisms were proposed. The tertiary
Analysis of human menisci degeneration via infrared attenuated total reflection spectroscopy.
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Degeneration of human meniscal tissue induces impairment of normal knee functions, and is a highly relevant etiology of knee joint tears and osteoarthritis. Currently, the grading scale of meniscus degeneration is conventionally derived from evaluating meniscal morphology and histological staining.
Neuroprotective effects of N-acetylcysteine amide on experimental focal penetrating brain injury in rats.
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We examined the effects of N-acetylcysteine amide (NACA) in the secondary inflammatory response following a novel method of focal penetrating traumatic brain injury (TBI) in rats. N-acetylcysteine (NAC) has limited but well-documented neuroprotective effects after experimental central nervous system
Changes in the concentrations of glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide during the lactation cycle in goats.
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Plasma concentrations of glucagon-like peptide-1(7-36)amide (GLP) and gastric inhibitory polypeptide (GIP) were determined at fortnightly intervals for over a year throughout the pregnancy-lactation cycle of goats. Both GIP and GLP concentrations were elevated during lactation and fell rapidly when
Preparation and characterization of tablet formulation based on solid dispersion of glimepiride and poly(ester amide) hyperbranched polymer.
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The feasibility of incorporating a solid dispersion containing poorly soluble antidiabetic drug glimepiride and poly(ester amide) hyperbranched polymer into a tablet using a direct-compression tabletting technique was investigated. Tablet cores were additionally coated with hydroxypropyl
The Eyes Have It: Eyelid Swelling and Rash in a 79-year-old Woman With Macular Degeneration.
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A 79-year-old woman with macular degeneration was referred to the Allergy/Immunology clinic for the evaluation of a potential allergy to anti-vascular endothelial growth factor (anti-VEGF) treatments. The patient developed urticaria and eyelid swelling immediately following a retinal
Preparation of novel anthranilic acids as antibacterial agents. Extensive evaluation of alternative amide bioisosteres connecting the A- and the B-rings.
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In the past few years, a significant effort has been devoted by Pharmacia toward the discovery of novel antibiotics. We have recently described the identification of an anthranilic acid lead 1 and the optimization resulting in the advanced lead 2. In this report, we describe the preparation of
Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands.
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Since the discovery that FK-506 promotes neurite outgrowth, considerable attention has been focused on the development of potent nonimmunosuppressive ligands for FK-506 binding proteins (FKBPs). Such neuroimmunophilin agents have been reported to show neuroregenerative activity in a variety of cell
Mixed complexes formed by lithioacetonitrile and chiral lithium amides: observation of (6)li,(15)N and (6)Li,(13)C couplings due to both C-Li and N-Li contacts.
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NMR spectroscopic studies have been performed on the mixed complexes formed by the lithium salt of acetonitrile (LiCH(2)CN) and the chiral lithium amides Li-(S)-N-(2-methoxybenzyl)-1-amino-1-phenyl-2-ethoxyethane (Li-1) and Li-(S)-N-isopropyl-2-amino-1-phenyl-3-methoxypropane (Li-2) in diethyl ether
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