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10 resultats
A new toxic alkylpyrrolidine alkaloid from Arisarum vulgare.
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From the tubers of Arisarum vulgare Targ. (Araceae), a new toxic alkylpyrrolidine alkaloid has been purified and characterized. By 2D COSY NMR spectroscopic methods, its structure was elucidated as: (-)- R- N-methyl-2-[9'-(2''-methoxyphenyl)nonyl]pyrrolidine.
DNA affinity of active alkaloids from Arisarum vulgare Targ.
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Some 2-alkylpyrrolidine and 2-alkylpiperidine alkaloids isolated from Arisarum vulgare Targ. demonstrated activity in a high-performance liquid chromatographic system designed to detect compounds capable of interacting with DNA. (-)-R-Bgugaine (N-H), an alkaloid prepared by synthesis, exhibited an
Bgugaine, a pyrrolidine alkaloid from Arisarum vulgare, is a strong hepatotoxin in rat and human liver cell cultures.
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Toxicity of bgugaine, a pyrrolidine alkaloid extracted from the tubers of Arisarum vulgare, was studied in three different liver cell culture models: (1) the rat hepatocyte primary culture; (2) a liver epithelial cell line; and (3) the human hepatoblastoma cell line HepG2. Cytotoxicity was evaluated
Irniine, a pyrrolidine alkaloid, isolated from Arisarum vulgare can induce apoptosis and/or necrosis in rat hepatocyte cultures.
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The effects of irniine, a pyrrolidine alkaloid extracted from the tubers of Arisarum vulgare, on rat hepatocyte primary cultures and rat liver epithelial cell line (RLEC) were studied. Cytotoxicity was first evaluated by LDH release, MTT and NR tests and MDA production, while cellular alterations
Cytotoxic effect and electrophysiological study on human MRC-5 fibroblasts of R-irniine, a natural alkylpyrrolidine alkaloid.
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R-irniine is a natural 2-alkylpyrrolidine alkaloid extracted from Arisarum vulgare Targ., a species belonging to the Araceae family known in Morocco for its toxicity. Cytotoxic and electrophysiological studies of this compound on human MRC-5 fibroblasts were carried out. Cytotoxic potential of
Cytotoxic effect and electrophysiologic activity of (R)-bgugaine, an alkylpyrrolidine alkaloid against MRC-5 fibroblasts.
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The cytotoxicity and the electrophysiological effects against MRC-5 fibroblasts of 2-alkylpyrrolidine, (-)-R-bgugaine [1], a natural alkaloid, extracted from Arisarum vulgare Targ., (Araceae) were studied. This compound showed a cytotoxic potential against MRC-5 fibroblasts at 10 microg/ml. The
Cytotoxic effect and electrophysiological activity of (S)-bgugaine, an alkylpyrrolidine alkaloid against MRC-5 fibroblasts.
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(+)-S-bgugaine [1], is an alkaloid prepared by enantioselective synthesis. This alkaloid is an isomer of R-bgugaine [2], an alkaloid isolated from Arisarum vulgare, an Araceae toxic plant of Morocco. The cytotoxic effect and the electrophysiological activity of (+)-S-bgugaine [1] against MRC-5
Anti-cancer effect of two alkaloids: 2R and 2S-bgugaine on mastocytoma P815 and carcinoma Hep.
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The 2-alkylpyrrolidine R-bgugaine, a natural alkaloid isolated from tubers of Arisarum vulgare Targ. Tozz. (Araceae), and its isomer S-bgugaine, obtained by an asymmetric synthesis, were examined for their cytotoxic activities on two cancerous cellular lines: the murine mastocytoma cell line P815
Synthesis of (R)-norbgugaine and its potential as quorum sensing inhibitor against Pseudomonas aeruginosa.
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(R)-Bgugaine is a natural pyrrolidine alkaloid from Arisarum vulgare, which shows antifungal and antibacterial activity. In this Letter, we have accomplished the simple synthesis of norbgugaine (demethylated form of natural bgugaine) employing Wittig olefination and cat. hydrogenation as the key
Cytotoxic effect and electrophysiological activity of S-irniine, a synthesised isomer of the natural R-irniine, on human MRC-5 fibroblasts.
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Numerous original alkaloids are present in tubers of Arisarum vulgare Targ. a species belonging to the Araceae family known in Morocco for its toxicity. Some previous works deal with the activity of these natural compounds as R-irniine. As the enantioselective total synthesis of irniine has been
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