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[Nephropathy caused by Chinese plants and aristolochic acids: from clinical observation to experimental model].

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In 1992, a new type of progressive renal fibrosis was reported in patients after the intake of weight-reducing pills containing a Chinese herb (Aristolochia fangchi) rich of nephrotoxic and carcinogenic aristolochic acids (AA). Up to now, Chinese herb nephropathy (CHN), also called aristolochic acid

Fatal renal failure due to the Chinese herb "GuanMu Tong" (Aristolochia manshuriensis): autopsy findings and review of literature.

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Herbal remedies have been used since ancient times and it is now known that they are not completely free of adverse effects. We present the case of a 41-year-old Chinese man, who died in renal failure because he consumed a herbal preparation called "Fen Qing Wu Lin Wan", having GuanMu Tong as main

Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose.

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BACKGROUND Renal failure after ingestion of Chinese herbs between 1990 and 1992 was related to the replacement of Stephania tetrandra by Aristolochia fangchi (ST-AF), containing nephrotoxic and carcinogenic aristolochic acids. However, the relationship between ST-AF and renal failure is still a

Phytochemical Analysis and Toxicity Study of Aristolochia paucinervis Rhizomes Decoction Used in Moroccan Alternative Medicine: Histopathological and Biochemical Profiles.

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Ethnopharmacological Relevance

Aristolochia paucinervis (A. paucinervis) (Aristolochiaceae) is a plant frequently used in Moroccan alternative medicine. The aim of the current study is to investigate the phytochemical composition of rhizomes decoction of A.

The combined toxicity of Aristolochia bracteata and Cadaba rotundifolia to goats.
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The sequential development of the clinical signs and lesions in the organs of Nubian goats fed on Aristolochia bracteata (Um Galagel) and Cadaba rotundifolia (Kurmut) and their mixture in certain proportions was studied. Kidney and liver function was tested and the results correlated with

Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice.
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BACKGROUND Longdan Xieganwan, which contains Aristolochia species, is a traditional Chinese prescription. It has been used for thousands of years to "enhance liver". However, many cases of Longdan Xieganwan induced nephropathy were reported recently. OBJECTIVE This study was designed to compare the

Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats.
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Chinese-herb nephropathy (CHN) is a rapidly progressive renal fibrosis associated with the intake of a Chinese herb (Aristolochia fangchi) containing nephrotoxic and carcinogenic aristolochic acids (AA). This study attempted to reproduce the main features of human CHN (renal failure, tubular

Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi).
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A new renal disease called 'Chinese-herb nephropathy' (CHN) has been reported to occur in women who have ingested slimming pills containing powdered extracts of the Chinese herb Stephania tetrandra (ST). Moderate to end-stage renal disease developed, requiring renal replacement therapy by dialysis

Possible role of mitochondrial injury in Caulis Aristolochia manshuriensis-induced chronic aristolochic acid nephropathy.
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BACKGROUND The proximal tubular epithelial cells (PTECs) are the primary target of aristolochic acids and especially vulnerable to mitochondrial injury from insults of toxic xenobiotics. OBJECTIVE This study aimed to investigate the possible role of mitochondrial injury in Caulis Aristolochia

Belgian (Chinese herb) nephropathy: why?
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During the last years several patients with renal failure were admitted in Brussels hospitals. The progressive interstitial fibrosis with tubular atrophy seen in these patients has been ascribed to the slimming therapy preceding the pathology. The nephropathy was remarkable with regard to its

[Chinese herbs-induced renal failure with Fanconi syndrome: a report of 6 cases].
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OBJECTIVE To understand the clinical and pathological features of patients with Fanconi syndrome associated with renal function damage induced by Chinese herbs. METHODS Six cases with herb-induced renal failure associated with Fanconi syndrome were clinicopathologically analyzed. RESULTS All six

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aristolochia wardiana/atròfia

[Nephropathy caused by Chinese plants and aristolochic acids: from clinical observation to experimental model].

Fatal renal failure due to the Chinese herb "GuanMu Tong" (Aristolochia manshuriensis): autopsy findings and review of literature.

Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose.

Phytochemical Analysis and Toxicity Study of Aristolochia paucinervis Rhizomes Decoction Used in Moroccan Alternative Medicine: Histopathological and Biochemical Profiles.

The combined toxicity of Aristolochia bracteata and Cadaba rotundifolia to goats.

Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice.

Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats.

Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi).

Possible role of mitochondrial injury in Caulis Aristolochia manshuriensis-induced chronic aristolochic acid nephropathy.

Belgian (Chinese herb) nephropathy: why?

[Chinese herbs-induced renal failure with Fanconi syndrome: a report of 6 cases].

La base de dades d’herbes medicinals més completa avalada per la ciència