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Pàgina 1 des de 37 resultats
2',4'-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds and their use as therapeutic agents
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TECHNICAL FIELD
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 2',4'-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds (collectively referred to herein as "DCBP compounds"). The present invention also pertains to
Phenylquinazolinecarboxylic acids and derivatives as cancer chemotherapeutic agents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to quinazoline-4-carboxylic acids, processes for preparing them, pharmaceutical compositions containing them and methods of using them as cancer chemotherapeutic agents.
2. Literature Background
Only a small number of
Compounds and methods for treating tumors, cancer and hyperproliferative diseases
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FIELD OF THE INVENTION
The present invention relates to novel compounds, pharmaceutical compositions and methods for treating tumors, cancer and hyperproliferative diseases including psoriasis, genital warts and hyperproliferative cell growth diseases, including hyperproliferative keratinocyte
Fluorinated thiazoles for use in treating cancer
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The present invention relates to new thiazole compounds, to pharmaceutical compositions containing them and to their use for the treatment of cancer.
BACKGROUND
Cancer is a heterogeneous disease characterized by the accumulation of tumor cells, which can cause the death of both animals and humans.
Biphenyl and biphenyl-analogous compounds as integrin antagonists
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FIELD OF THE INVENTION
The present invention relates to new biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer,
Biphenyl and biphenyl-analogous compounds as integrin antagonists
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FIELD OF THE INVENTION
The present invention relates to new biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer,
Biphenyl and biphenyl-analogous compounds as integrin antagonists
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FIELD OF THE INVENTION
The present invention relates to new biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer,
Antiandrogenic biphenyls
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BACKGROUND OF THE INVENTION
This invention relates to novel inhibitors of sex steroid activity such as antiandrogenic compounds having effective antagonistic activity while substantially lacking agonistic effects. More particularly, the invention relates to certain biphenyl derivatives and their
1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione
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BACKGROUND
The present invention relates to 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione derivatives, to pharmaceutical compositions comprising the same and to the use of these 1-(biphenyl-4-ylmethyl)imidazolidine-2,4-dione derivatives in therapy, especially in the treatment of pain.
Pain is an
Substituted biphenyl analogues as dual inhibitors of aromatase and sulfatase
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CROSS REFERENCE TO RELATED APPLICATION
This application is a 35 U.S.C. 371 National Phase of PCT Application No. PCT/CN2013/091085 filed Dec. 31, 2013, the disclosure of this prior application is hereby incorporated in their entirety by reference.
The present invention relates to new biphenyl
Substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-one
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The present invention relates to substituted 3-(biphenyl-3-yl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]dec-3-en-2-ones, in particular for therapeutic purposes, to pharmaceutical compositions comprising the compounds according to the invention and to their use in therapy, in particular for the prophylaxis
Biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases
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BACKGROUND OF THE INVENTION
The present invention relates to novel biphenyl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy
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The present invention relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions comprising the compounds according to the invention and to their use in therapy, in particular for the
Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy and halogen-substituted spirocyclic ketoenols
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The present invention relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions comprising the compounds according to the invention and to their use in therapy, in particular for the
Biphenyl hydroxy imino butyric acids and their derivatives for treating arthritis
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BACKGROUND OF THE INVENTION
The present invention relates to novel biphenyl butyric acid compounds and their derivatives useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to
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