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10 resultats
Pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl] benzimidazole-7-carboxylate or a pharmaceutically acceptable salt thereof and compositions and method of pharmaceutical use thereof
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SUMMARY OF THE INVENTION
The present invention provides pivaloyloxymethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl[benzimidazole-7-carboxylat e having potent anti-hypertensive activity and strong angiotensin II antagonistic action, which are of practical value in clinical use as therapeutic
1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-c arboxylate and compositions and methods of pharmaceutical use thereof
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SUMMARY OF THE INVENTION
In a first aspect of the invention there is provided 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-car boxylate, including certain stable forms as well as pharmaceutically acceptable salts, which have
Potent
Substituted biphenyl derivatives
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The invention relates to compounds of the formula I ##STR2##
in which: R.sup.1 is: phenyl or naphthyl, which is substituted by --C(.dbd.NH)NH.sub.2, that can also be monosubstituted by --COA, --CO--[C(R.sup.7).sub.2 ].sub.n -Ar', --COOA, --OR.sup.7, --OCOA, --OCO--[C(R.sup.7).sub.2 ].sub.n -Ar' or
Biphenyl compounds useful or endothelin antagonists
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SUMMARY OF THE INVENTION
This invention is concerned with non-peptidic endothelin receptor antagonists represented by the compound of Formula I, pharmaceutical compositions containing these compounds, as well as combination therapies which include a compound of the present invention. The compounds
7-[(4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B
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FIELD OF THE INVENTION
This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,
7[4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B
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FIELD OF THE INVENTION
This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,
Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to compounds having inhibitory activity against the biosynthesis of triglycerides and inhibitory activity against the secretion of lipoprotein containing apolipoprotein B, and prophylactic or therapeutic agents for
Substituted triazoles as angiotensin II inhibitors
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FIELD OF THE INVENTION
This invention relates to novel compounds of the following formulae: ##STR1##
The invention also relates to pharmaceutical compositions comprising a compound of the invention as the active ingredient, a method of treating a physiological condition in mammals that is mediated
Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to compounds having inhibitory activity against the biosynthesis of triglycerides and inhibitory activity against the secretion of lipoprotein containing apolipoprotein B, and prophylactic or therapeutic agents for
Benzimidazole derivative compositions and medical use thereof
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SUMMARY OF THE INVENTION
The present invention provides 1-acetoxyethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-car boxylate having potent anti-hypertensive activity and strong angiotensin II antagonistic action, which is of practical value in clinical use as
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