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broad/inflamació
L'enllaç es desa al porta-retalls
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Flavonoids: Broad Spectrum Agents on Chronic Inflammation.
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Flavonoids are major plant constituents with numerous biological/pharmacological actions both in vitro and in vivo. Of these actions, their anti-inflammatory action is prominent. They can regulate transcription of many proinflammatory genes such as cyclooxygenase- 2/inducible nitric
Broad-spectrum cardioprotection with adenosine.
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Ischemia-reperfusion results in contractile dysfunction, necrosis, and vascular injury. This postischemic injury is mediated in part by superoxide radical production, neutrophils, dysfunction to ionic pumps, and edema formation. Adenosine is an autacoid released tonically by myocytes, endothelium,
Cardiac glycosides are broad-spectrum senolytics.
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Senescence is a cellular stress response that results in the stable arrest of old, damaged or preneoplastic cells. Oncogene-induced senescence is tumor suppressive but can also exacerbate tumorigenesis through the secretion of pro-inflammatory factors from senescent cells. Drugs that selectively
Broad spectrum immune monitoring in immune-mediated inflammatory disorders.
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Broad-spectrum antiviral properties of andrographolide.
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Andrographolide, a diterpenoid, is known for its anti-inflammatory effects. It can be isolated from various plants of the genus Andrographis, commonly known as 'creat'. This purified compound has been tested for its anti-inflammatory effects in various stressful conditions, such as ischemia,
Anti-inflammatory drug development: Broad or specific chemokine receptor antagonists?
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Chemokines and chemokine receptors form a complex and diverse system known to be relevant for leukocyte activation and trafficking. There has been significant interest in the development of anti-inflammatory drugs that antagonize the function of chemokines or their receptors. However, the
From dog to man: the broad spectrum of inflammatory myopathies.
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The purpose of this review is to describe the various forms of inflammatory myopathy that occur spontaneously in dogs, and discuss the similarities and differences between inflammatory myopathy in dogs and humans. Some interesting muscle-specific autoantigens have recently been discovered in canine
Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors.
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A series of 3-acylaminocaprolactams are inhibitors of chemokine-induced chemotaxis. Branching of the side chain alpha-carbon provides highly potent inhibitors of a range of CC and CXC chemokines. The most potent compound has an ED(50) of 40 pM. Selected compounds were tested in an in vivo
Ginger--an herbal medicinal product with broad anti-inflammatory actions.
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The anti-inflammatory properties of ginger have been known and valued for centuries. During the past 25 years, many laboratories have provided scientific support for the long-held belief that ginger contains constituents with antiinflammatory properties. The original discovery of ginger's inhibitory
[Adiponectin--adipocytokine with a broad clinical spectrum].
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Adiponectin (also called AdipoQ, gelatin-binding protein 28, Acrp30) is a novel adipocytokine with important metabolic effects. It is physiologically released from adipose tissue and circulates in serum as a hexamer and larger multimeric structure of high molecular weight. Serum level of the protein
The broad homeostatic role of natriuretic peptides.
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A brief non-inclusive review on natriuretic peptides (NP), their receptors, and their main functional properties is presented. The three main NP, atrial (ANP), brain (BNP) and C-type (CNP) are considered. Guanylyl cyclase receptors modulate all the known systemic effects of NP. Clearance receptors
Neutrophilic dermatoses: a broad spectrum of disease.
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The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical
Do MDL-1⁺ cells play a broad role in acute inflammation?
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Dengue virus (DV) reacts with myeloid DAP12-associating lectin-1 (MDL-1) on immature polymorphonuclear leukocytes. Interaction of DV with MDL-1+ cells triggers systemic inflammatory response syndrome (SIRS) and dengue shock syndrome (DSS), with subsequent multi-organ failure. In this issue of the
Inflammatory Pathways in CVD and Diabetes: Broad-Spectrum Versus Selective Targeting.
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Ciclopirox: a broad-spectrum antifungal with antibacterial and anti-inflammatory properties.
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