Catalan
Albanian
Arabic
Armenian
Azerbaijani
Belarusian
Bengali
Bosnian
Catalan
Czech
Danish
Deutsch
Dutch
English
Estonian
Finnish
Français
Greek
Haitian Creole
Hebrew
Hindi
Hungarian
Icelandic
Indonesian
Irish
Italian
Japanese
Korean
Latvian
Lithuanian
Macedonian
Mongolian
Norwegian
Persian
Polish
Portuguese
Romanian
Russian
Serbian
Slovak
Slovenian
Spanish
Swahili
Swedish
Turkish
Ukrainian
Vietnamese
Български
中文(简体)
中文(繁體)
Pàgina 1 des de 2851 resultats
Broad-spectrum allosteric inhibition of herpesvirus proteases.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, previously shown to disrupt dimerization of Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and two analogues generated through carboxylate
Structural basis for broad specificity in alpha-lytic protease mutants.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
Binding pocket mutants of alpha-lytic protease (Met 192----Ala and Met 213----Ala) have been constructed recently in an effort to create a protease specific for Met just prior to the scissile bond. Instead, mutation resulted in proteases with extraordinarily broad specificity profiles and high
Characterization of a broad pH range protease of Candida caseinolytica.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
OBJECTIVE
The study of a protease secreted by Candida caseinolytica for use in future industrial applications.
RESULTS
Growth of Candida caseinolytica on a medium containing milk induced a rapid production of an extracellular enzyme able to hydrolyse casein. The crude extract was applied to both
Quantifying missing (phospho)proteome regions with the broad-specificity protease subtilisin.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
Despite huge efforts to map the human proteome using mass spectrometry the overall sequence coverage achieved to date is still below 50%. Reasons for missing areas of the proteome comprise protease-resistant domains including the lack/excess of enzymatic cleavage sites, nonunique peptide sequences,
Novel broad-spectrum activity-based probes to profile malarial cysteine proteases.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
Clan CA cysteine proteases, also known as papain-like proteases, play important roles throughout the malaria parasite life cycle and are therefore potential drug targets to treat this disease and prevent its transmission. In order to study the biological function of these proteases and to chemically
Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
Clinically approved inhibitors of the HIV-1 protease function via a competitive mechanism. A particular vulnerability of competitive inhibitors is their sensitivity to increases in substrate concentration, as may occur during virion assembly, budding and processing into a mature infectious viral
The Arabidopsis AtSTE24 is a CAAX protease with broad substrate specificity.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
Following prenylation, the proteins are subject to two prenyl-dependent modifications at their C-terminal end, which are required for their subcellular targeting. First, the three C-terminal residues of the CAAX box prenylation signaling motif are removed, which is followed by methylation of the
Broad Susceptibility of Nucleolar Proteins and Autoantigens to Complement C1 Protease Degradation.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
Anti-nuclear autoantibodies, which frequently target the nucleoli, are pathogenic hallmarks of systemic lupus erythematosus (SLE). Although the causes of these Abs remain broad and ill-defined, a genetic deficiency in C1 complex (C1qC1r2C1s2) or C4 is able to induce these Abs. Considering a recent
A new broad-spectrum protease inhibitor from the entomopathogenic bacterium Photorhabdus luminescens.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
A new protease inhibitor was purified to apparent homogeneity from a culture medium of Photorhabdus luminescens by ammonium sulfate precipitation and preparative isoelectric focusing followed by affinity chromatography. Ph. luminescens, a bacterium symbiotically associated with the insect-parasitic
A fluorescent oligopeptide energy transfer assay with broad applications for neutral proteases.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
A fluorescent peptide substrate to explore the protease specificity for the amino acid regions C- and N-terminal to the cleavage site has been designed. Intramolecular quenching of indole fluorescence by an N-terminal dansyl group separated by six amino acid residues forms the basis of this assay.
Correction: Novel broad-spectrum activity-based probes to profile malarial cysteine proteases.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
[This corrects the article DOI: 10.1371/journal.pone.0227341.].
Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
Alpha2-macroglobulin (alpha2M) is a major human blood glycoprotein best known for its ability to inhibit a broad spectrum of proteases by a unique trapping method. This action induces an "activated" conformation of alpha2M with an exposed binding site for the low-density lipoprotein receptor,
In silico characterization of broad range proteases produced by Serratia marcescens EGD-HP20.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
In the present study, Serratia marcescens EGD-HP20 strain was demonstrated to utilize poultry waste comprising of both white non-melanized and dark/brown melanized poultry feathers. The potential of the isolate to hydrolyze diverse keratinous wastes was further corroborated by comparative genomics
ZapA, a possible virulence factor from Proteus mirabilis exhibits broad protease substrate specificity.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
The opportunistic bacterium Proteus mirabilis secretes a metalloprotease, ZapA, considered to be one of its virulence factors due to its IgA-degrading activity. However, the substrate specificity of this enzyme has not yet been fully characterized. In the present study we used fluorescent peptides
Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses.
Només els usuaris registrats poden traduir articles
Inicieu sessió / registreu-vos
Feline infectious peritonitis and virulent, systemic calicivirus infection are caused by certain types of feline coronaviruses (FCoVs) and feline caliciviruses (FCVs), respectively, and are important infectious diseases with high fatality rates in members of the Felidae family. While FCoV and FCV
La base de dades d’herbes medicinals més completa avalada per la ciència
- Funciona en 55 idiomes
- Cures a base d'herbes recolzades per la ciència
- Reconeixement d’herbes per imatge
- Mapa GPS interactiu: etiqueta les herbes a la ubicació (properament)
- Llegiu publicacions científiques relacionades amb la vostra cerca
- Cerqueu herbes medicinals pels seus efectes
- Organitzeu els vostres interessos i estigueu al dia de les novetats, els assajos clínics i les patents
Escriviu un símptoma o una malaltia i llegiu sobre herbes que us poden ajudar, escriviu una herba i vegeu malalties i símptomes contra els quals s’utilitza.
* Tota la informació es basa en investigacions científiques publicades
