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carbonic anhydrase/nàusea

L'enllaç es desa al porta-retalls
10 resultats

A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors.

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SLC-0111 is an ureido-substituted benzenesulfonamide small molecule inhibitor of carbonic anhydrase IX. The objectives of this first-in-human Phase 1 study were to determine the safety and tolerability of SLC-0111 in patients with advanced solid tumors and to establish the recommended

Carbonic anhydrase inhibitors and high altitude illnesses.

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Carbonic anhydrase (CA) inhibitors, particularly acetazolamide, have been used at high altitude for decades to prevent or reduce acute mountain sickness (AMS), a syndrome of symptomatic intolerance to altitude characterized by headache, nausea, fatigue, anorexia and poor sleep. Principally CA

Can migraine prophylaxis prevent acute mountain sickness at high altitude?

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Acute mountain sickness (AMS) develops in people trekking at high altitude. The underlying mechanism is vasodilation due to low pressure of oxygen. However, individual susceptibility for AMS is unknown, thus, one cannot predict when or to whom it happens. Because AMS usually begins with headache,

[Mountain sickness].

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Mountaineering brings many health risks, one of which is mountain sickness. Its mildest form - acute mountain sickness - is mainly characterized by subjective symptoms (headache, loss of appetite, insomnia, weakness, nausea and rarely also vomiting). Advanced and life-threatening forms are

The Effects of Acetazolamide on Exercise Performance at Sea Level and in Hypoxic Environments: A Review.

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Lowlanders rapidly ascending to high altitude (>2500 m) often develop acute mountain sickness (AMS). While acclimatization is the most effective method of reducing symptoms of AMS (ie, headache, fatigue, nausea, gastrointestinal distress, etc.), it may take several days to become fully acclimated.

A trial of dorzolamide for glaucoma.

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OBJECTIVE To determine whether the effectiveness of dorzolamide changes when the drug is used under routine clinical conditions versus the more ideal conditions of a clinical trial. METHODS A total of 118 eyes of 65 patients were assessed. Nine patients (15 eyes) received dorzolamide only, 41

[Successful treatment with topiramate in a case of idiopathic intracranial hypertension refractory to acetazolamide].

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A 6-year-old girl experienced nausea and vomiting for 3 weeks and double vision for 1 week prior to her first visit to our hospital. She had bilateral ophthalmoplegia from sixth cranial nerve palsy and papilledema. Her brain MRI showed normal brain parenchyma. The lumbar cerebrospinal fluid (CSF)

Topiramate: Comprehensive profile.

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Topiramate, 2,3:4,5-di-O-isopropylidene-β-d-fructopyranose sulfamate, is a potent antiepileptic drug with a broad spectrum of activity. It is effective in both partial and generalized seizures. Topiramate was also found to have significant efficacy in migraine prevention with considerable reductions

CNS adverse events associated with antiepileptic drugs.

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A variety of newer antiepileptic drugs (AEDs) are now available for treating patients with epilepsy in addition to the 'conventional' drugs that have been available throughout a large part of the last century. Since these drugs act to suppress the pathological neuronal hyperexcitability that

Altitude, Acute Mountain Sickness, and Acetazolamide: Recommendations for Rapid Ascent

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Toussaint, Claudia M., Robert W. Kenefick, Frank A. Petrassi, Stephen R. Muza, and Nisha Charkoudian. Altitude, acute mountain sickness, and acetazolamide: recommendations for rapid ascent. High Alt Med Biol. 00:000-000, 2020. Background: Sea level natives ascending rapidly to
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