ELGANs recruited to the study group in addition to standard of care will have continuous cerebral NIRS monitoring for the initial 72 hours and TNE studies at definitive time frames and a hemodynamic report will be provided to the clinical team using the results of the multimodal monitoring and clinical data. The report will be a description of the hemodynamic status without any suggestions for management.

ELGANs recruited into Standard arm will have the standard monitoring including cardiorespiratory monitoring. The invasive blood pressure monitoring, NIRS and TNE monitoring as per the clinical team's discretion - consistent with the current standard of care. No hemodynamic report will be provided routinely.

Hemodynamic Instability

The multimodal data comprising the clinical, biochemical, NIRS data and TNE where available will be used by the study team in such cases to reach a description of the hemodynamic status of the study infant and will be provided to the Clinical team.

Hemodynamic report

Royal Alexandra Hospital-NICU

Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit

Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit- Non-Blinded Randomized Control Trial

Higher the scores, higher the cardiovascular support

for the purpose of Validation of Vasoactive-Ventilation-Renal scores in the transition neonatal period

Kumar Kumaran

Clinical Assistant Professor, University of Alberta,

University of Alberta

Participants on complete bed rest group kept antepartum confinement to bed with toileting restricted to bedpan use. Participants in this group received prophylactic subcutaneous enoxaparin (40mg/day).

Activity restriction group had motion limited to bathroom privileges and walks to the ward canteen four times per day.

Preterm Premature Rupture of Membrane

Patient eligibility is based on gender identity because we will include only pregnant women

Patients in this group received standard care for PPROM according to the institution protocol, including antepartum confinement to bed.

complete bed rest

Patients in this group received standard care for PPROM according to the institution protocol but to had bathroom privileges and walks to the ward canteen four times per day.

activity restriction

Bed Rest After Preterm Premature Rupture of the Membranes

A Pilot Randomized Controlled Trial On Complete Bed Rest Versus Activity Restriction After Preterm Premature Rupture of the Membranes

Time between preterm premature rupture of the membranes and delivery, in days

Incidence of clinical chorioamnionitis (defined as maternal fever plus leukocytosis and CRP elevation, or as maternal fever plus any two of the following: fetal tachycardia; maternal tachycardia; uterine tenderness; purulent amniotic fluid)

Inês Martins

Medical Doctor, Principal Investigator

Centro Hospitalar Lisboa Norte

The intervention group will be women with premature preterm rupture of membranes (pProm), suffering from IAI

Venous blood samples and placental blood samples

Blood sampling

Medical University of Vienna

mtDNA as Novel Biomarker for Intra-amniotic Infection

Circulating Cell-free Mitochondrial as a Novel Biomarker for Intra-amniotic Infection in Obstetrics

Herbert Kiss

MD, PhD

Study arm was fed with probiotics as infloran 125mg/kg/dose twice daily by adding it to breast milk or mixed feeding (breast and formula) for 6 weeks; the control arm was fed with breast milk or mixed feeding without probiotics.

Enterocolitis, Necrotizing

Study group was fed with probiotics as infloran 125mg/kg/dose twice daily by adding it to breast milk or mixed feeding (breast and formula) for 6 weeks;

infloran

Study group was fed with infloran [Lactobacilli acidophilus (CFU 109 NCDO 1748, obtained from the National Collection of Dairy Organisms)] and Bifidobacteria bifidum [(CFU 109, NCDO 1453 obtained from the National Collection of Dairy Organisms)]; Laboratorio Farmaceutico S.I.T S.r.I ITALY] 125mg/kg/dose twice daily by adding it to breast milk or mixed feeding (breast and formula) for 6 weeks;

Department of Pediatrics, Children Hospital, China Medical University, Taichung, Taiwan

Probiotics Reduce Incidence of Necrotizing Enterocolitis for Very Low Birth Weight Infants

Phase 2 Study of Oral Probiotics Reduce the Incidence and Severity of Necrotizing Enterocolitis for Very Low Birth Weight Infants -Multi-Center Randomized Control Trial

chorioamnionitis/hypoxia

Multimodal Monitoring of Hemodynamics in Extremely Low Birth Weight Preterm Infant in a Canadian Tertiary Level Unit

Bed Rest After Preterm Premature Rupture of the Membranes

mtDNA as Novel Biomarker for Intra-amniotic Infection

Probiotics Reduce Incidence of Necrotizing Enterocolitis for Very Low Birth Weight Infants

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