patients with emesis gravidarum who take a chewing gum with vitamin C (verum) "ad libitum" several times daily for 2 weeks

patients with emesis gravidarum who take chewing gum without vitamin C (placebo) "ad libitum" several times daily for 2 weeks

patients with emesis gravidarum who do not use chewing gum during the study phase

Hyperemesis Gravidarum

Nausea Gravidarum

Vitamin C Deficiency

Using a chewing gum with 150mg vitamin C (per piece/gum) for 14 days "ad libitum"

Pregnan-C-Gum(R) chewing gum

Using a chewing gum without vitamin C (per piece/gum) for 14 days "ad libitum"

Placebo chewing gum

Medical University of Vienna, Dept. of Obstetrics and Gynecology

Chewing Gum Containing Vitamin-c to Treat Emesis Gravidarum

Chewing Gum Containing Vitamin-c to Treat Emesis Gravidarum: a Randomized Controlled Trial

validated questionnaire describing individual nausea

Alex Farr, MD PhD

Assistant Professor, Consultant Physician

Medical University of Vienna

Motion Sickness

DPI-386 Nasal Gel

DPI-386 Placebo Nasal Gel

Transderm Scop®

NAMRU-D

DPI 386 Nasal Gel for the Prevention of Nausea Associated With Motion Sickness

A Randomized, Double-Blind Placebo-Controlled Phase 3 Study of the Safety, Pharmacokinetics, and Efficacy of DPI 386 Nasal Gel for the Prevention of Nausea Associated With Motion Sickness

Repurposed Therapeutics, Inc.

The sample size of 54 allows for an equal distribution of subjects within gender and treatment arm: 18 subjects per treatment arm with 9 per gender.

This study is double‐blinded for the DPI‐386 Nasal Gel and placebo nasal gel arms. All DPI‐386 Nasal Gel and placebo nasal gel vials are opaque and indistinguishable. The DPI‐386 Nasal Gel and placebo nasal gel are identical in color and viscosity, and without identifiable smell.

Administration of GeoLab Association (acetylsalicylic acid, sodium bicarbonate and citric acid)

Treatment of Episodic Tension Headache

Association: acetylsalicylic acid (500mg), sodium bicarbonate (1625) and citric acid (965)

1 tablet in an episody of headache (Aspirin 500mg)

Aspirin - Bayer

Lal Clinica Pesquisa E Desenvolvimento Ltda

Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache.

citric acid/vòmit

Chewing Gum Containing Vitamin-c to Treat Emesis Gravidarum

DPI 386 Nasal Gel for the Prevention of Nausea Associated With Motion Sickness

Efficacy and Safety Clinical Trial of the Combination of Acetylsalicylic Acid, Sodium Bicarbonate and Citric Acid, Produced by Geolab Pharmaceutical Industries Ltd., Compared to Acetylsalicylic Acid (Aspirin ® - Bayer) in Patients With Episodic Tension-type Headache.

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