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Pàgina 1 des de 2501 resultats
Early age renal synovial sarcoma.
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OBJECTIVE
We report a primary renal Synovial Sarcoma (SS) case and analyze its features.
METHODS
A 15 year old male presented with left abdominal mass and weight loss. CT scan images showed a 13 cm mass located in the lower pole of the left kidney. Renal biopsy recognized an undifferentiated
Adjuvant chemotherapy in early uterine sarcoma.
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Nine years' experience with early uterine sarcoma is reviewed. In addition to hysterectomy and radiotherapy, 34 patients received adjunctive chemotherapy; 67 patients received no adjunctive chemotherapy. Seventeen patients who received chemotherapy received combination vincristine, 1.5 mg/m2 weekly;
The early clinical presentation of synovial sarcoma.
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While synovial sarcoma most commonly presents as a painless mass, occasionally the cancer emerges in a misleading manner resulting in an unfavorable delay or error in diagnosis. A review of the litrature reveals 4 such occult patterns: pretumor phase characterized only by pain or tenderness; the
Kaposi's sarcoma-associated herpesvirus immediate early gene activity.
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KSHV is the causative agent of three human proliferative disorders: Kaposi s sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. Herpesvirus gene expression and viral replication is a complex, tightly regulated process involving latent, immediate early, early, and late viral
Treatment of early uterine sarcomas: disentangling adjuvant modalities.
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Uterine sarcomas are a rare group of neoplasms with aggressive clinical course and poor prognosis. They are classified into four main histological subtypes in order of decreasing incidence: carcinosarcomas, leiomyosarcomas, endometrial stromal sarcomas and "other" sarcomas. The pathological subtype
Adjuvant chemotherapy in early stage uterine sarcomas: an open question.
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Uterine sarcomas are aggressive gynecological cancers even at early stage of disease. The most common histological types are represented by leiomyosarcoma, endometrial stromal sarcoma, and carcinosarcoma. The mainstay of treatment of stage I-II disease is total hysterectomy with bilateral
Translating genomic risk into an early detection strategy for sarcoma.
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Sarcomas have a strong genetic etiology, and the study of families affected by sarcomas has informed much of what we now understand of modern cancer biology. The recent emergence of powerful genetic technologies has led to astonishing reductions in costs and increased throughput. In the clinic,
Brain tumors of early infants.
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The authors describe their experience with ten cases of brain tumors in children in whom the onset of symptoms occurred within the first year of life, but who were operated on when they were 2 months to 4 years of age. The series includes 5 gliomas (4 supratentorial, 1 cerebellar; 3 astrocytomas, 1
Early clinical trial with quelamycin.
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Quelamycin (triferric doxorubicin) is a derivative of Adriamycin with different pharmacologic properties. Our phase I clinical study of quelamycin includes 37 patients with a wide spectrum of solid tumors. The recommended dose in good-risk patients is 150 mg/m2, given as a 1-hour infusion every 3
Surgery and radiotherapy in the treatment of early stage uterine sarcomas.
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Twenty-three patients with early stage uterine sarcomas underwent surgery (5 patients) or surgery and pelvic irradiation (18 patients). Twelve (52%) of the patients developed a recurrence: relapsing disease was pelvic in 3 (25%) of them, extrapelvic in 8 (66.7%) and both pelvic and extrapelvic in
Early manifestations of vitamin D effects in rat osteogenic sarcoma cells.
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We have recently demonstrated that 48 hour exposure of ROS 17/2 cells to low concentrations of 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) (1.0 pg/ml) stimulated the cellular accumulation of 45Ca, and exposure to high concentrations (160 pg/ml) inhibited such accumulation. In the present study,
The Current Landscape of Early Drug Development for Patients With Sarcoma.
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Until recently, advancements in the treatment of patients with adult soft tissue sarcomas have been relatively slow. This is, in part, due to their heterogeneity and rarity. A better understanding of the biology and differences among the various histologies has led to substantial growth in novel
Early results of combined modality therapy of patients with Ewing's sarcoma.
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Fourteen patients with localized Ewing's sarcoma were treated with radiation therapy to the involved bone and systemic chemotherapy. Nine patients remained free of disease for a median follow-up period of 3 years. The actuarial 5-year disease-free survival rate is 60%.
Identification of HHV8 in early Kaposi's sarcoma: implications for Kaposi's sarcoma pathogenesis.
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OBJECTIVE
Kaposi's sarcoma is a vascular tumour of uncertain pathogenesis possibly caused by an infectious agent, identified in high risk groups. Accumulating solution phase polymerase chain reaction (PCR) and seroepidemiological data suggest that a previously undescribed herpes DNA virus (human
High incidence, early onset of histiocytic sarcomas in mice with Hertwig's anemia.
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Histiocytic sarcoma (HS) is a rare, rapidly disseminated, usually lethal tumor in humans. Treatment specific for HS has not been developed primarily due to deficiencies of appropriate animal models with high incidence/early onset. Mice with Hertwig's anemia (an/an) provide a potential
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