Two capsules containing starch and glucose, once per day, 60 days duration

One capsule 250 mg active compound (OPP) and one capsule containing starch and glucose, once per day, 60 days duration

One capsule containing 1000 mg active compound (OPP) and one capsule starch and glucose, once per day, 60 days duration

Two capsules, 1000 mg active compound (OPP) each, once per day, 60 days duration

Cardiovascular Diseases

Hyperlipidemias

Hypercholesterolemia

The placebo that will be used contains starch and glucose.

Placebos

One capsule contains 250 mg OPP or 1 g OPP

Oil Palm Phenolics

National University of Malaysia

Supplementation of Oil Palm Phenolics to Healthy Participants

Supplementation of Oil Palm Phenolics to Improve Lipid Profile in Healthy Participants (Phase I Clinical Trial Study)

This will be assessed from the plasma analysis on the fasting blood samples of each participant

This will be assessed via history, physical examination, kidney function test, liver function test and hematology profile from the plasma analysis on the fasting blood samples of each participant.

This will be assessed from the plasma analysis on the fasting blood samples of each participant.

Inflammatory markers such as Interleukin-6, Interleukin-1beta, Tumour Necrosis Factor-alpha, Interleukin-10 and interferon-Gamma will be assessed from the plasma analysis on the fasting blood samples of each participant.

Antioxidant levels such as Malonaldehyde and Superoxide dismutase will be assessed from the plasma analysis on the fasting blood samples of each participant.

This will be assessed by measuring the weight of each participant.

Isa Naina Mohamed

Associate Professor

Malaysia Palm Oil Board

Colorectal Neoplasms

participants drinks a fat-free milk shakes

Fat-free milkshake

participants drinks the milk shakes prepared from 60g of olive oil

Olive oil

participants drinks the milk shakes prepared from 60g of soybean oil

Soybean oil

participants drinks the milk shakes prepared from 60g of fried soybean oil

Fried soybean oil

participants drinks the milk shakes prepared from 60g of palm oil

Palm oil

participants drinks the milk shakes prepared from 60g of fried palm oil

Fried palm oil

participants drinks the milk shakes prepared from 60g of camellia oil

Camellia oil

participants drinks the milk shakes prepared from 60g of fried camellia oil

Fried camellia oil

participants drinks the milk shakes prepared from 60g of tallow

Tallow

participants drinks the milk shakes prepared from 60g of fried tallow

Fried tallow

The Effects of Various Cooking Oils on Health Related Biomarkers in Healthy Subjects

This is a metabolomics study. We measured retention time (min), mass and abundance of serum metabolites with LC-QTOF at 3 time points. Then, we compared the abundance of metabolites between different oil consumption time ( before and after ) and assessed the health effects of cooking oils.

Wen-Harn Pan

Institute of Biomedical Sciences

Academia Sinica, Taiwan

500 mg gallic acid equivalent (GAE), twice daily, 12 months

Prediabetes

Placebo

Seberang Jaya Hospital

Modulating Effects of Oil Palm Phenolics in Subjects With Pre-diabetes

Serum Glycosylated Haemogoblin (<5.7% indicates healthy, 5.7% - 6.4% indicates prediabetes, >6.5% indicates diabetes)
Plasma glucose level of oral glucose tolerance test (<7.8 mmol/L indicates healthy, 7.8 mmol/L - 11 mmol/L indicates prediabetes, >11 mmol/L indicates diabetes)
Fasting plasma glucose level (<5.6 mmol/L indicates healthy, 5.6 mmol/L - 6.9 mmol/L indicates prediabetes, >6.9 mmol/L indicates diabetes)

Model-derived Oral Glucose Insulin Sensitivity (OGIS) Index will be calculated using weight (kg), height (cm), glucose (mmol/L) and insulin (pmol/L).

Total cholesterol, Low-density lipoprotein, High-density lipoprotein, Triglycerides

Very good, good, no change, unsatisfactory and very unsatisfactory

Homeostatic Model Assessment (HOMA2-B) to determine beta cell function

Yuen Kah Hay

Professor, Dr.

Universiti Sains Malaysia

Clinical Research Centre, Malaysia

500 mg gallic acid equivalent (GAE), twice daily, 3 months

Uncontrolled Insulin-treated Type 2 Diabetes Mellitus

Modulating Effects of Oil Palm Phenolics in Uncontrolled Insulin-treated Type 2 Diabetes Mellitus

Very good, Good, No change, Unsatisfactory, Very unsatisfactory

Cardiovascular Risk Factor

Red Palm Olein contains corresponding fatty acids like Palm Olein except having more phytonutrients (carotenoids and vitamin E)

Red Palm Olein

Palm Olein contains corresponding fatty acids like Red Palm Olein except having less phytonutrients (no carotenoids and less vitamin E)

elaeis guineensis/antioxidant

Supplementation of Oil Palm Phenolics to Healthy Participants

The Effects of Various Cooking Oils on Health Related Biomarkers in Healthy Subjects

Modulating Effects of Oil Palm Phenolics in Subjects With Pre-diabetes

Modulating Effects of Oil Palm Phenolics in Uncontrolled Insulin-treated Type 2 Diabetes Mellitus

Red Palm Olein and Cardiovascular Health

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