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8 resultats
Friedelin inhibits the growth and metastasis of human leukemia cells via modulation of MEK/ERK and PI3K/AKT signalling pathways
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Purpose: Leukemia constitutes just 3% of all malignancies but because of its high incidence and mortality in children and persons below 40 years of age, it is considered one of the devastating malignant conditions. This study was
Effects of 8-Hydroxyisocapnolactone-2-3-diol and friedelin on mast cell degranulation.
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OBJECTIVE
To investigate the effects of friedelin (terpenoid) and 8-hydroxyisocapnolactone-2-3-diol (coumarin) with concentration 10 μM, 30 μM, and 100 μM on inhibiting mast cells (MCs) degranulation.
METHODS
The investigation was performed in vitro by administering each compound into rat peritoneal
Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells.
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A new friedelane-type triterpene (1), along with seven known triterpenoids, was isolated from the stems and leaves of Calophyllum inophyllum Linn. Their structures were established as 3beta, 23-epoxy-friedelan-28-oic acid (1), friedelin (2), epifriedelanol (3), canophyllal (4), canophyllol (5),
Evaluation of Polygonum bistorta for anticancer potential using selected cancer cell lines.
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The chloroform and hexane fractions and their sub-fractions of Polygonum bistorta (Polygonaceae) were evaluated for their cytotoxic activity against P338 (Murine lymphocytic leukaemia), HepG2 (Hepatocellular carcinoma), J82 (Bladder transitional carcinoma), HL60 (Human leukaemia), MCF7 (Human breast
Xanthones from the seeds of Allanblackia monticola and their apoptotic and antiproliferative activities.
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Phytochemical investigations of the seeds of ALLANBLACKIA MONTICOLA have led to the isolation and characterization of one new xanthone derivative, named allanxanthone E ( 1), together with seven known compounds, including five xanthones, 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone ( 2),
Mucigerin, a new coumarin from Calophyllum mucigerum (Guttiferae).
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Our recent studies on the stem bark of Calophyllum mucigerum (Guttiferae) have yielded a new coumarin mucigerin, a prenylated xanthone cudraxanthone C and the common steroidal triterpenes friedelin and stigmasterol. Structural elucidations of these compounds were achieved using 1H NMR, 13C NMR,
Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity.
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As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, Dichapetalum pallidum, led to the isolation of the newly occurring 7-hydroxydichapetalin P (1) and the known dichapetalins A (2) and X (3).
Cytotoxic activities of chemical constituents from Mesua daphnifolia.
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Detail chemical investigations on the stem bark of Mesua daphnifolia gave three triterpenoids and four xanthones. They are friedelin (1), friedelan-1,3-dione (2), lup-20(29)- en-3ss-ol (3), cudraxanthone G (4), ananixanthone (5), 1,3,5-trihydroxy-4-methoxyxanthone (6) and euxanthone (7). These
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