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Pàgina 1 des de 22 resultats
WBQ5187, a Multitarget, Directed Agent, Ameliorates Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease and Modulates Cerebral β-amyloid, Gliosis, cAMP Levels and Neurodegeneration.
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Previously, we designed, synthesized and evaluated a series of quinolone-benzofuran derivatives as multitargeted anti-Alzheimer's disease (anti-AD) compounds, and we discovered that WBQ5187 possesses superior anti-AD bioactivity. In this work, we investigated the pharmacokinetics of this new
[Multiple cerebral telangiectasias. Apropos of an anatoma-radioclinical case].
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Telangiectasias are vascular malformations corresponding to dilated capillary separated by nervous parenchyma. They are generally asymptomatic and discovered during autopsy.
METHODS
We describe the case of a 2-year-old girl who was admitted for drowsiness and vomitings with craniomegaly and right
Acute, relapsing brain oedema with diffuse blood-brain barrier alteration and axonal damage in the acquired immunodeficiency syndrome.
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A 38-year-old homosexual male with AIDS suffered four neurological episodes including headaches, confusion, visual impairment, memory disturbances, and dysarthria which resolved spontaneously in a few days. He was admitted to hospital during a fifth episode. Neurological examination revealed a
STUDIES ON THE NERVOUS SYSTEM IN DEFICIENCY DISEASES : II. LESIONS PRODUCED IN THE DOG BY DIETS LACKING THE WATER-SOLUBLE, HEAT-STABLE VITAMIN B(2)(G).
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Adult dogs maintained on an artificial, balanced ration adequate in all dietary essentials as far as is known except water-soluble, heat-stable vitamin B(2) (G) developed, after a sufficient time, a slowly progressive disease characterized by loss of weight, persistent vomiting and diarrhea, and
[Krabbe s disease - case report]
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OBJECTIVE: Report a case of Krabbés disease with necropsy. METHODS: Review of medical and necropsy records. RESULTS: An 8 months-old male patient developed tremors, swallowing difficulty and excessive salivation for 4 months prior to admission, evolving with vomiting and fever. Physical examination
Atypical presentation and neuropathological studies in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.
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A 6 1/2-month-old male offspring of consanguineous Egyptian parents was first seen because of fever, somnolence, vomiting, right focal motor seizures, right hemiparesis, elevated transaminase levels, hyperammonemia, and acidosis. A computed tomographic scan of the head suggested swelling of the left
Spongy degeneration of the CNS in infancy.
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We studied six cases of spongy degeneration of the CNS in infancy among Chinese. The main clinical features were cyclical vomiting and wailing, blindness, megalocephaly, convulsions, lethargy, and coma. Chief findings from light microscopic studies were spongiform change, moderate outfall of
Lhermitte-Duclos disease with atypical vascularization--case report and review of the literature.
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OBJECTIVE
A case of Lhermitte-Duclos disease (LDD, dysplastic gangliocytoma) with atypical vascularization is reported. LDD is a rare cerebellar mass lesion which may be associated with Cowden's syndrome and the PTEN germline mutation.
METHODS
A 61-year-old male presented 15 years before with a
Pseudorabies in a dog.
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Pseudorabies was diagnosed in a 5-year-old female crossbred dog by histologic examination and virus isolation. The clinical signs were depression, salivation, head pressing, and emesis. There were no gross pathologic findings. The microscopic findings in the brain stem consisted of mononuclear cell
Leigh's subacute necrotizing encephalomyelopathy: possible diagnosis by CT scan.
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A 28-month-old Korean girl developed a rapidly progressive disease, characterized by disturbance of consciousness, tremor, nystagmus, ophthalmoplegia, irregular deep respiration and vomiting. The patient succumbed 2 weeks after the onset of the illness. CT scan disclosed bilaterally symmetrical, low
Neurotoxicity of local administration of two nitrosoureas in malignant gliomas.
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The neurotoxicity of local administration of nitrosoureas in malignant gliomas was investigated clinicopathologically. Twenty patients were entered into this study: 13 were treated with 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and 7 with methyl
[A clinicopathological study of demyelination pseudotumors of the brain].
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OBJECTIVE
To study the clinicopathological characteristics diagnosis, differential diagnosis and etiology of demyelination pseudotumors of the brain.
METHODS
The clinical features, CT, MRI scan findings, corticosteroid therapeutic effects and follow-up data of 3 cases of demyelination pseudotumors
[Cerebrovascular disease as an initial finding in childhood tuberculosis meningoencephalitis].
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BACKGROUND
The prevalence of tuberculosis in developing countries, such as Brazil, remains high with important morbidity and mortality rates among children. Neurological complications are frequent and tuberculous meningo-encephalitis (TBM) is the most dreaded of them in infancy.
METHODS
Our case
Natural West Nile virus infection in a captive juvenile Arctic wolf (Canis lupus).
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A case of West Nile virus (WNV) infection in a captive 4-month-old Arctic wolf (Canis lupus) is described. The animal had vomiting, anorexia, and ataxia before death. Histopathology revealed multifocal severe renal lymphoplasmacytic vasculitis, mostly affecting small arterioles, with fibrinoid
The association of infantile osteopetrosis and neuronal storage disease in two brothers.
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Neurological manifestations in infantile osteopetrosis are common and varied, and not always attributable to the skeletal pathology. An unusual association of osteopetrosis with neuronal storage of ceroid lipofuscin is reported in two infant brothers born of nonconsanguinous parents. The first child
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