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heart failure/triacylglycerol
L'enllaç es desa al porta-retalls
Pàgina 1 des de 34 resultats
Exercise training reduces circulating adiponectin levels in patients with chronic heart failure.
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High adiponectin concentrations have emerged as an independent risk factor of outcome inpatients with CHF (chronic heart failure); however, modification of adiponectin in CHF patients has not been assessed to date. The aim of the present study was to investigate the effect of exercise training on
Atorvastatin decreases triacylglycerol-associated risk of vascular events in coronary heart disease patients.
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High triacylglycerol (TAG) levels may predict vascular risk. The effect of a statin-induced reduction in TAG levels, irrespective of HDL-C increase, on clinical outcome has not yet been addressed by an endpoint study in patients with coronary heart disease (CHD). The GREACE study compared usual with
Changes in fatty acid compositions of myocardial lipids in rats with heart failure following myocardial infarction.
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Changes in fatty acid composition of myocardial lipids were examined in rats with heart failure following myocardial infarction. Left ventricular systolic pressure (LVSP) was decreased and left ventricular end-diastolic pressure (LVEDP) was elevated 24 h, 1 and 12 weeks after left coronary artery
Cardiovascular disease, heart failure, chronic kidney disease and depression independently increase the risk of incident diabetes.
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OBJECTIVE
Diabetes increases the risk of cardiovascular disease (CVD) and heart failure, as well as other serious complications, such as renal disease and depression. However, these conditions are often present prior to diabetes diagnosis. We sought to determine whether they increase the risk of
Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload.
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OBJECTIVE
Development of heart failure is known to be associated with changes in energy substrate metabolism. Information on the changes in energy substrate metabolism that occur in heart failure is limited and results vary depending on the methods employed. Our aim is to characterize the changes in
Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.
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Advanced HF (heart failure) is associated with altered substrate metabolism. Whether modification of substrate use improves the course of HF remains unknown. The antihyperglycaemic drug MET (metformin) affects substrate metabolism, and its use might be associated with improved outcome in diabetic
The absence of endogenous lipid oxidation in early stage heart failure exposes limits in lipid storage and turnover.
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Intramyocardial lipid handling in pressure-overload-induced heart failure remains poorly understood, and the balance between endogenous and exogenous lipid utilization for mitochondrial ATP production is essentially unknown. In this study, we determined the contribution of endogenous
Luteolin ameliorates cardiac failure in type I diabetic cardiomyopathy.
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OBJECTIVE
The study aimed to determine whether luteolin can confer cardioprotective effects against diabetic cardiomyopathy in relation to specific and quantitative markers of oxidative stress.
METHODS
We examined diabetic cardiomyopathy by left ventricular hemodynamic analysis. Myocardial oxidative
Acute cardiovascular toxicity of sterilizers, PHMG, and PGH: severe inflammation in human cells and heart failure in zebrafish.
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In 2011, dozens of children and pregnant women in Korea died by exposure to sterilizer for household humidifier, such as Oxy(®) and Cefu(®). Until now, however, it remains unknown how the sterilizer affect the human health to cause the acute deaths. To find its toxicity for organ, we investigated
Western diet increases cardiac ceramide content in healthy and hypertrophied hearts.
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OBJECTIVE
Obesity and cardiac left ventricular hypertrophy (LVH) are recognised independent risk factors in the development of heart failure (HF). However, the combination of these factors may exacerbate the onset of cardiovascular disease by mechanisms as yet unclear. LVH leads to significant
Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat.
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BACKGROUND
Diabetic cardiomyopathy (DCM) contributes to cardiac failure in diabetic patients. It is characterized by excessive lipids accumulation, with increased triacylglycerol (TAG) stores, and fibrosis in left ventricle (LV). The mechanisms responsible are incompletely known and no specific
Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy.
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Dilated cardiomyopathy (DCM), a common cause of heart failure, is characterized by cardiac dilation and reduced left ventricular ejection fraction, but the underlying mechanisms remain unclear. To investigate the mechanistic basis, we performed global metabolomic analysis of myocardial tissues from
Sarcolemmal fatty acid uptake vs. mitochondrial beta-oxidation as target to regress cardiac insulin resistance.
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Cardiomyopathy and heart failure are frequent comorbid conditions in type-2 diabetic patients. However, it has become increasingly evident that insulin resistance, type-2 diabetes, and cardiomyopathy are not independent variables, and are linked through changes in metabolism. Specifically, elevated
Effects of acute stress on cardiac endocannabinoids, lipogenesis, and inflammation in rats.
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OBJECTIVE
Trauma exposure can precipitate acute stress (AS) and cardiovascular disorders (CVD). Identifying AS-related physiologic changes that affect CVD risk could inform development of early CVD prevention strategies. The endocannabinoid system (ECS) regulates hypothalamic-pituitary-adrenal axis
Effects of doxazosin on functional alterations of isolated coronary arteries from cholesterol-fed rabbits.
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Anti-hypertensive treatment is much less successful at reducing coronary artery disease than at reducing mortality from stroke and congestive heart failure. The effects of the alpha-adrenergic antagonist doxazosin on progression of atheromatous lesions and functional responses of isolated coronary
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