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Pàgina 1 des de 36 resultats
Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
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INTRODUCTION
Technical Field
The field of this invention is compounds and their use in the treatment of prostate cancer and hyper-androgenic syndromes including alopecia, hirsutism and acne vulgaris.
Background
The existence of a number of pathologic syndromes depends on androgen hormones. Thus,
Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
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TECHNICAL FIELD
The field of this invention is compounds and their use in the treatment of prostate cancer and hyper-androgenic syndromes including alopecia, hirsutism and acne vulgaris.
BACKGROUND
The existence of a number of pathologic syndromes depends on androgen hormones. Thus, growth of
Cloning and expression of dog gonadotropin releasing hormone receptor
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FIELD OF THE INVENTION
This invention relates to the cloning and isolation of the dog gonadotropin-releasing hormone (GnRH) receptor, and also to mutant or polymorphic forms of the receptor and recombinant nucleic acids encoding the same. The invention also relates to genetically engineered host
Method for treatment of alopecia
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The present invention relates to a novel composition useful in the treatment of alopecia female hirsutism or seborrhea or in the prevention of bone metastasis caused by prostatic cancer.
BACKGROUND OF THE INVENTION
Excessive stimulation of androgenic hormones such as dihydrotestosterone (DHT) causes
Compositions and treatments for reducing potential unwanted side effects associated with long-term administration of androgenic testosterone precursors
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BACKGROUND OF THE INVENTION
A. Field of the Invention
The invention relates to the use of nutrient combinations to prevent or reduce potential adverse effects from administration of androgenic testosterone precursors to humans and other mammals Specifically, the invention relates to
Antiandrogenic biphenyls
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BACKGROUND OF THE INVENTION
This invention relates to novel inhibitors of sex steroid activity such as antiandrogenic compounds having effective antagonistic activity while substantially lacking agonistic effects. More particularly, the invention relates to certain biphenyl derivatives and their
Steroid 5A-reductases
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to enzymes, termed steroid 5.alpha.-reductases, which function biologically to catalyse the conversion of testosterone to dihydroxytestosterone. Accordingly, the invention relates to the preparation of this
Indole derivatives useful as testosterone 5.alpha.-reductase inhibitors
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This application is a National Stage application of PCT/JP94/00406, filed Mar. 14, 1994, which published as WO94/22821 on Oct. 13, 1994.
TECHNICAL FIELD
The present invention relates to novel indole derivatives and pharmaceutically acceptable salts thereof. More particularly, it relates to novel
Inhibitors for testosterone 5.alpha.-reductase activity
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FIELD OF THE INVENTION
This invention relates to pharmaceutical compositions and methods for the treatment of androgen-related diseases, said compositions having novel inhibitors of testosterone 5.alpha.-reductase activity. The inhibitors have a good combination of inhibitory effect on
Steroid 5a reductase nucleic acid segments and recombinant vectors and host cells
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1. Field of the Invention
The present invention relates generally to enzymes, termed steroid 5.alpha.-reductases, which function biologically to catalyse the conversion of testosterone to dihydroxytestosterone. Accordingly, the invention relates to the preparation of this enzyme from various sources
Substituted 3-phenanthridinone derivatives as 5-alpha-reductase inhibitors
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FIELD OF THE INVENTION
The present invention provides novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action rely on the selective inhibition of the
Compositions and methods for inhibiting 5-.alpha. reductase
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FIELD OF THE INVENTION
The present invention pertains to compositions and methods for treating disease. In particular, the instant invention pertains to regulating 5-.alpha. reductase and thereby affect the physiological process leading to certain diseases.
BACKGROUND OF THE INVENTION
There are two
20-fluoro-17(20)-vinyl steroids
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to 20-fluoropregna-5,17(20)-diene-3.beta.,21-diol, 20-fluoro-pregna-5,17(20)-dien-3.beta.-ol and related compounds, to processes for their preparation, and to compositions incorporating these compounds as well as the
17.beta.-substituted 4-aza-5.alpha.-androstan-3-one derivatives
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The present invention relates to novel 17.beta.-substituted 4-aza-5.alpha.-androstan-3-one derivatives, to a process for their preparation, and to pharmaceutical compositions containing them. These compounds are inhibitors of androgen action, by means of testosterone 5.alpha.-reductase
Human androgen receptor DNA-binding domain (DBD) compounds as therapeutics and methods for their use
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TECHNICAL FIELD
This invention relates to therapeutic compounds and compositions, and methods for their use in the treatment of various indications, including various cancers. In particular the invention relates to therapies and methods of treatment for cancers such as prostate
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