There will be one group of patients, that will use salicylic acid peeling on the right side of the face and topical Silymarin cream on the left side

Acne Vulgaris

Silymarin 1.4% cream will be used on the left side of the face twice daily (home use).

Silymarin

Patients will have salicylic acid 30% peeling on the right side of the face as a peeling session every two weeks. Sessions will be done by well trained physician.

Salicylic acid

Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris

Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study

counting the number of inflammatory, non-inflammatory and total lesions at baseline and every 4 weeks during the treatment

interviewing the patients about any sign/symptom of adverse reactions (erythema, peeling, burning sensation, dryness and pruritus)

Alaa Gamal Ahmed Makhlouf

Principal investigator

Assiut University

Patients will use salicylic acid 30% peeling on the right side of the face and topical Silymarin 1.4% cream on the left side.

White bread consumption on the study visit

Blood Pressure

further fasting

white bread consumption

mango consumption

Regal Human Nutrition Research Center

The Acute Effect of Mango Intake (Mangifera Indica L.) on Blood Pressure and Blood Glucose

Changes in measures of blood pressure (mmHg) from baseline to two hours following fasting or consumption of white bread or mango.

Changes in blood glucose from baseline to two hours following fasting or consumption of white bread or mango.

Changes in insulin from baseline to two hours following fasting or consumption of white bread or mango.

University of California, Davis

National Mango Board

USDA Beltsville Human Nutrition Research Center

500 mg gallic acid equivalent (GAE), twice daily, 12 months

Prediabetes

Oil Palm Phenolics

Placebo

Seberang Jaya Hospital

Modulating Effects of Oil Palm Phenolics in Subjects With Pre-diabetes

Serum Glycosylated Haemogoblin (<5.7% indicates healthy, 5.7% - 6.4% indicates prediabetes, >6.5% indicates diabetes)
Plasma glucose level of oral glucose tolerance test (<7.8 mmol/L indicates healthy, 7.8 mmol/L - 11 mmol/L indicates prediabetes, >11 mmol/L indicates diabetes)
Fasting plasma glucose level (<5.6 mmol/L indicates healthy, 5.6 mmol/L - 6.9 mmol/L indicates prediabetes, >6.9 mmol/L indicates diabetes)

Model-derived Oral Glucose Insulin Sensitivity (OGIS) Index will be calculated using weight (kg), height (cm), glucose (mmol/L) and insulin (pmol/L).

Total cholesterol, Low-density lipoprotein, High-density lipoprotein, Triglycerides

Very good, good, no change, unsatisfactory and very unsatisfactory

Homeostatic Model Assessment (HOMA2-B) to determine beta cell function

Yuen Kah Hay

Professor, Dr.

Universiti Sains Malaysia

Malaysia Palm Oil Board

Clinical Research Centre, Malaysia

500 mg gallic acid equivalent (GAE), twice daily, 3 months

Uncontrolled Insulin-treated Type 2 Diabetes Mellitus

Modulating Effects of Oil Palm Phenolics in Uncontrolled Insulin-treated Type 2 Diabetes Mellitus

Very good, Good, No change, Unsatisfactory, Very unsatisfactory

hydroxybenzoic acid/inflamació

Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris

The Acute Effect of Mango Intake (Mangifera Indica L.) on Blood Pressure and Blood Glucose

Modulating Effects of Oil Palm Phenolics in Subjects With Pre-diabetes

Modulating Effects of Oil Palm Phenolics in Uncontrolled Insulin-treated Type 2 Diabetes Mellitus

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