It will be accepted as the control group and 4 experimental burn wounds will be created on the back of the rats in the group and no treatment will be given.

4 experimental burn wounds will be created on the back of the rats in the group and dressing with 1% Silver Sulfadiazine will be done on the back of the rats every day for 21 days.

4 experimental burn wounds will be created on the back of the rats in the group and dressing with %0.2 Nitrafurozon will be done on the back of the rats every day for 21 days.

4 experimental burn wounds will be created on the back of the rats in the group and dressing with 10% Propolis will be done on the back of the rats every day for 21 days.

4 experimental burn wounds will be created on the back of the rats in the group and dressing with 15% Propolis will be done on the back of the rats every day for 21 days.

4 experimental burn wounds will be created on the back of the rats in the group and dressing with Propolis vehicle will be done on the back of the rats every day for 21 days.

Burns

Burn Wound

st. group: It will be considered as a control group and rats will not be treated.
nd. group: Vehicle group, Propolis vehicle will be applied topically to rats for 21 days.
rd group: Silver Sulfadiazine group, 1% Silver Sulfadiazine will be applied topically to rats for 21 days.
th. group: Nitrafurozon group, 0.2% Nitrafurozon will be applied topically for 21 days.
th. group: 10% Propolis group, 10% Propolis will be applied topically for 21 days.
th. group: 15% Propolis group, 15% Propolis will be applied topically for 21 days.

burn wound dressing

Effect of Propolis Application on Burn Healing

Effect of Topical Turkish Propolis Application on Burn Healing in Experimental Burn Model

will be studied for the evaluation of acute phase reactants.

will be studied for the evaluation of oxidative stress

will be studied for the evaluation of collagen

will be studied for the evaluation of fibrosis

photos will be taken every day to determine the wound size

examination of the skin at the light microscopic level. Bulla will be considered as present or absent.

examination of the skin at the light microscopic level. Erythemawill be considered as present or absent.

examination of the skin at the light microscopic level. Edema will be considered as present or absent.

examination of the skin at the light microscopic level. Inflammatory cell infiltration will be considered as present or absent.

examination of the skin at the light microscopic level. Necrosis will be considered as present or absent.

examination of the skin at the light microscopic level. Ulceration will be considered as present or absent.

examination of the skin at the light microscopic level. Angiogenesis will be considered as present or absent.

examination of the skin at the light microscopic level. Neovascularization will be considered as present or absent.

examination of the skin at the light microscopic level. Fibroblast proliferation will be considered as present or absent.

examination of the skin at the light microscopic level. Epithelization will be considered as present or absent.

examination of the skin at the light microscopic level. Umber will be considered as present or absent.

examination of the skin at the light microscopic level. Damage will be considered as present or absent.

the study's data is planned to be published and shared in a scientific paper

ESRA ARDAHAN AKGUL

Research Assistant

Izmir Katip Celebi University

1st. group: It will be considered as a control group and rats will not be treated.
2nd. group: Vehicle group, Propolis vehicle will be applied to rats for 21 days.
3rd. group: Silver Sulfadiazine group, 1% Silver Sulfadiazine will be applied topically to rats for 21 days.
4th. group: Nitrafurozon group, 0.2% Nitrafurozon will be applied topically for 21 days.
5th. group: 10% Propolis group, 10% Propolis will be applied topically for 21 days.
6th. group: 15% Propolis group, 15% Propolis will be applied topically for 21 days.

the researcher who will analyze the primary outcome of the study will not know which group of animals the samples were taken from.

Herbal formula treatment PROLUNG in additional to current therapy

Idiopathic Pulmonary Fibrosis

Chinese herbal medicine formula PROLUNG with individual herbs of the formula are listed as follows (weight in granule preparation):
Huang Qi (Radix Astragali Membranaceus): 2 g
Dan Shen (Radix Salviae Miltiorrhizae): 1 g
Jiang Huang (Rhizoma Curcumae Longae): 1 g
Yin Xing (Semen Gingko Bilobae): 1 g
Mai Men Dong (Tuber Ophiopogonis Japonoci): 1 g
Bai He (Bulbus Lilii): 1g
Jin Yin Hua (Flos Lonicerae Japonicae): 1 g
Zi Su Ye (Folium Perillae Frutescentis): 1 g
Yin Yang Huo (Herba Epimedii): 1g

PROLUNG

Queen Mary Hospital

Clinical Trial of Chinese Herbal Medicine for Idiopathic Pulmonary Fibrosis (IPF)

The Effectiveness of an Empirical Chinese Medicine Formulation for Idiopathic Pulmonary Fibrosis: an Open Label Clinical Trial

Annual rate of change in forced expiratory vital capacity (FVC) will serve the primary outcome.

The St. George's Respiratory Questionnaire (SGRQ) will be used to additionally assess respiratory functions.

The 36-Item Short Form Survey (SF-36) is a 36-question questionnaire to assess the quality of life of a participant in terms of physical and mental health.

The WHOQOL-BREF measures the physical and psychological health, the social relationships, and the environment of an individual.

All patients will be monitored for adverse reactions of any kind including but not limited to idiosyncratic allergic reactions to some components of the treatment.

Prof. Zhang Zhang-Jin

Professor, Associate Director (Clinical Affairs)

The University of Hong Kong

Queen Mary Hospital, Hong Kong

Overweight

Pre Diabetes

Diabetes Mellitus Type 2 Without Complication

This was a cross-sectional study in which participants were subjected to a screening phase before being eligible to participate in the study. All subjects were submitted to Laser-Doppler methods (assessment of microcirculatory blood flow), bioimpedance analysis (assessment of body composition), venous blood collections (laboratory analysis), and Finometer Pro (assessment of heart rate variability and blood pressure variability).

Laser-Doppler methods

DPP4 Activity, Microvascular Reactivity and Inflammation

Dipeptidyl Peptidase 4 (DPP4) Activity and Its Associations With Endothelial Dysfunction, Inflammatory and Metabolic Markers, Heart Rate and Blood Pressure Variability, and Measures of Adiposity in Subjects With Different Grades of Glucose Tolerance

Intergroup analysis of the associations between DPP4 activity and skin microvascular reactivity (blood flux and vasomotion evaluated by Laser-Doppler methods) - baseline assessment and at 30 and 60 min after a standardized meal intake (ingested over 3 minutes)

Intergroup analysis of the associations between DPP4 activity and markers of inflammation - baseline assessment and at 30 and 60 min after a standardized meal intake (ingested over 3 minutes)

Intergroup comparisons between the associations of DPP4 activity and Biochemical parameters (including gut peptides) - baseline assessment and at 30 and 60 min after a standardized meal intake (ingested over 3 minutes)

Intergroup analysis of the associations between DPP4 activity and insulin resistance indexes, heart rate and blood pressure variability (evaluated by Finometer Pro), and measures of adiposity at baseline

Luiz Guilherme Kraemer-Aguiar, MD

Professor

Rio de Janeiro State University

The study population consists of 100 enrolled patients with different stages of knee OA and varus malalignment >4° with respect to the mechanical loading axis of the lower extremity. A minimum of 40 patients are to be included per year, so that the study period will be planned from January 1st, 2015 to June 30th, 2017. Preliminary results will be reviewed by the end of every year and intermediate reports will be generated by the sub-study-groups

In order to investigate cartilage degeneration/turnover (COMP, collagen II, GAGs), miRNA and cytokine profiles 4 blood draws will be carried out

Osteoarthritis

Identification of Biochemical and Biomechanical Markers for Cartilage Degeneration in the Knee Joint (IBBM-CKJ)

The association between varus malalignment and dynamic knee loading / adduction moment and progression of knee joint cartilage degeneration in the lateral compartment is unclear and has not been studied in detail before. There is a need to identify relevant parameters explaining this cause-effect relationship. It is the purpose of the study to correlate load changes in knee joints with biomechanical and biochemical alterations in cartilage to understand the underlying mechanism of load induced cartilage degeneration in patients. This study will therefore include patients with different stages of knee OA with various malalignments. Moreover, analyzing changes in cartilage morphology, radiography and MRI and correlate those findings with alterations in biochemical parameters in cartilage, serum, urine and synovial fluid will allow us to identify novel biomarkers for the onset and progression of joint cartilage degeneration in varus malaligned knees.

hydroxyproline/inflamació

Effect of Propolis Application on Burn Healing

Clinical Trial of Chinese Herbal Medicine for Idiopathic Pulmonary Fibrosis (IPF)

DPP4 Activity, Microvascular Reactivity and Inflammation

Identification of Biochemical and Biomechanical Markers for Cartilage Degeneration in the Knee Joint (IBBM-CKJ)

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