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Hypericum for fatigue - a pilot study.

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Fatigue is a common reason for consulting a doctor but there is no definitive treatment. Hypericum perforatum has been shown to reduce symptoms of fatigue in depressed patients. It therefore may have potential value as a remedy for fatigue of unexplained origin. This pilot study aimed to investigate

Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome.

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Chronic fatigue syndrome (CFS) is an illness characterized by persistent and relapsing fatigue, often accompanied by numerous symptoms involving various body systems. The etiology of CFS remains unclear; however, a number of studies have shown that oxidative stress may be involved in its

Role of antioxidants in chronic fatigue syndrome in mice.

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The present study was carried out using mice model of chronic fatigue syndrome (CFS) in which mice were forced to swim everyday for 7 days for a 6 min session. There was a significant increase in despair behavior (immobility period) in saline treated mice on successive days. Treatment with potent

Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil.

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Hypericum Perforatum Extract is an extract of the capsules, flowers, leaves, and stem heads of Hypericum perforatum, commonly called St. John's Wort. Hypericum Perforatum Oil is the fixed oil from H. perforatum. Techniques for preparing Hypericum Perforatum Extract include crushing in stabilized

A review of clinical and experimental observations about antidepressant actions and side effects produced by Hypericum perforatum extracts.

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Hypericum perforatum is an herbaceous perennial plant, also known as "St. John's wort", used popularly as a natural antidepressant. Although some clinical and experimental studies suggest it has some properties similar to conventional antidepressants, the proposed mechanism of action seems to be

LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model.

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BACKGROUND St John׳s Wort (Hypericum perforatum, SJW) is a widely used herbal medicine in western countries but also an important Uygur drug in China. Hypericin (HY) is the main components in SJW extracts, which is used to treat fatigue, weakness, and mild depression. The aim of this study was to

[Suicidal and aggressive thoughts as a result of taking a Hypericum preparation (St. John's wort)].

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A 51-year-old woman presented at the internal medical outpatients' clinic complaining of fatigue. She had been having frightening suicidal and homicidal thoughts for about 9 months prior to coming to the clinic. Physical examination and extensive laboratory examination revealed no abnormalities. She

Hypericum treatment of mild depressions with somatic symptoms.

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In a randomized, placebo-controlled, double-blind study, 39 patients with depression with somatic symptoms were treated with hypericum extract LI 160. The therapy lasted for 4 weeks; the dosage was 300 mg three times daily. At the onset of the study as well as after 2 and 4 weeks, the following

[Atypical depression and related illnesses--neurobiological principles for their treatment with Hypericum extract].

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Atypical depression, somatoform disorder, neurasthenia and fibromyalgia seem to form a spectrum of disorders, who share a common biological basis, i.e. a reduced activity of the hypothalamus-pituitary-adrenocortical (HPA)-system. This is similar to the situation in Cushing's disease, where the

Effects of Hypericum extract (LI160) on the change of auditory evoked potentials by cortisol administration.

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Target symptoms treated with Hypericum extract, i.e. somatisation, fatigue and depression could be related to an increased activity of glucocorticoids in the brain. One potential mechanism is the increased permeability of the blood-brain barrier for glucocorticoids. Hypericum extract LI160 reduces

Epidemiology, etiology, and natural treatment of seasonal affective disorder.

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There is much more seasonal difference in higher latitudes than in lower latitudes. In a significant portion of the population of the northern United States, the shorter days of fall and winter precipitate a syndrome that can consist of depression, fatigue, hypersomnolence, hyperphagia, carbohydrate

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