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We describe a patient with rheumatoid arthritis (RA) who developed hypersensitivity after 3 weeks of therapy with azathioprine with fever, jaundice and renal insufficiency. A percutaneous liver biopsy was compatible with hypersensitivity hepatitis. During azathioprine rechallenge, the symptoms
We report the case of a 51-year-old patient with a Paget von Schrötter-Syndrome of the right arm who underwent a successful lysis therapy with 9 x 10(6) IU streptokinase (Streptase) i.v. over 3 days. 36 h after ending the lysis therapy he developed a generalized eczema, which was interpreted as a
We report a case of a severe hypersensitivity syndrome reaction to clopidogrel that resolved with dechallenge and recurred on rechallenge. The reaction included neutropenia, rash, fever, tachycardia, nausea, and vomiting. This presentation is very similar to the frequently reported hypersensitivity
Asthma and hay fever are likely to share hundreds if not thousands of genetic risk variants. Despite this, the extent to which the power to identify shared risk variants could be improved by considering information from both diseases when designing or analyzing genetic studies has not been studied
We describe a case of severe sulfasalazine allergy. Exacerbation of the symptoms occurred after unintentional rechallenge with co-trimoxazole, indicating that the reaction was triggered by the sulphonamide component. The clinical picture consisted of generalised adenopathy, hepatitis, high fever and
UNASSIGNED
The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood in a single cohort.
UNASSIGNED
This prospective study is based on a longitudinal birth cohort of 253 participants, with respiratory and
Seasonal allergic rhinitis (hay fever) is considered a disease of the postindustrial revolution era. Clinical reports of patients are readily available from the 19th century starting with John Bostock's description of his own summer symptoms. Also patients with "rose catarrh' are described in the
A 32-year-old HIV-infected woman developed fever and systemic illness of unknown origin after being placed on phenytoin for seizures. Her clinical syndrome, skin biopsy findings, and clinical response to steroids were consistent with phenytoin hypersensitivity syndrome.
The hypothesis presented proposes the involvement of a systemic form of a delayed-type hypersensitivity reaction in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome. It envisages the activation of sensitized T lymphocytes during a secondary infection by viral antigen present on the
A case of allergic rash associated with malignant hyperthermia (body temperature of 41 C) occurred in a patient who had been taking 400 mg of thioridazine hydrochloride (Mellaril) daily for two days. The condition responded well to supportive measures and immediate discontinuation of the drug use.
Grazax is a self-administered, once-daily, tablet-based vaccine that offers an alternative to allergy shots for adults with grass pollen allergy (hay fever). (2) Evidence from three randomized controlled trials indicates modest improvements in hay fever symptoms, with reduced use of medication to
Hay fever is an allergic reaction to pollen, and is seasonal (Spring to Autumn). Allergic rhinitis is a similar allergic reaction to substances such as house-dust mite, fungal spores or animal hairs, and tends to occur throughout the year. Both are common in the population, affecting one in five to
Local hyperthermia (43 degrees C) to the upper respiratory passages, without supplementary drugs, relieves symptoms of perennial allergic rhinitis. Treatment consisted of 3, 30 minute sessions at 1-hour intervals during a single day. 69% were free of their symptoms during the month following
Q fever has been associated with granulomatous changes in clinical biopsy material obtained from liver and bone marrow. Local reactions to skin testing have been described in previously sensitized humans, but histological studies of such reactions have not been reported. We note that delayed
Milk protein allergy is described in a young adult female patient who presented with fever and malabsorption syndrome. The patient fulfilled Goldman's criteria for the diagnosis of milk protein allergy and responded to an elimination diet.