Hypoxia / inflamació

Modulation of immune response and inflammation by targeting hypoxia inducible factors

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FIELD OF THE INVENTION This application relates to the field of immune response, specifically to the use of bioactive agents (compounds) that interfere with HIF-1.alpha. expression and/or transcriptional activities and HIF-1.alpha. inhibitors and therefore modulate (i.e. decrease or increase)

Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses

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TECHNICAL FIELD The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) gene products in a hypoxic cell. More particularly, the presently disclosed subject matter provides methods and

Inhibition of hypoxia-inducible factor activity with carica papaya extracts

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FIELD OF THE INVENTION The invention relates to the inhibition of hypoxia-inducible factor activity. BACKGROUND OF THE INVENTION The use of plant extracts in Traditional Chinese Medicine (TCM) can be traced back to 6000 years ago (Solecki and Shanidar, 1975). In recent years, there has been a

Inhibition of hypoxia-inducible factor activity with Carica papaya extracts

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FIELD OF THE INVENTION The invention relates to the inhibition of hypoxia-inducible factor activity. BACKGROUND OF THE INVENTION The use of plant extracts in Traditional Chinese Medicine (TCM) can be traced back to 6000 years ago (Solecki and Shanidar, 1975). In recent years, there has been a

Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof

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FIELD OF THE INVENTION This invention relates to a class of 2-nitroimidazole compounds, most preferably those bearing a cluster of boron atoms for boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat or prevent hypoxic conditions, e.g., cancer, inflammation, and

Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof

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FIELD OF THE INVENTION This invention relates to a class of 2-nitroimidazole compounds, most preferably those bearing a cluster of boron atoms for boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat or prevent hypoxic conditions, e.g., cancer, inflammation, and

Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury

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FIELD OF THE INVENTION The present invention relates generally to a method for modulating the inflammatory response induced in a mammal following tissue injury. More particularly, this invention relates to a method for alleviating immune-cell mediated tissue destruction associated with the

Method and apparatus for detection of vulnerable atherosclerotic plaque

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention generally relates to methods of diagnosing and treating inflammation, particularly inflamed atherosclerotic plaque at risk of rupture or thrombosis. More particularly, the methods of the invention pertain to the simultaneous

Devices and methods for using endovascular cooling to treat septic shock and other disorders

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FIELD OF THE INVENTION This invention relates generally to methods for medical treatment and more particularly to the use of endovascular heat exchange devices to treat sepsis, septic shock or other disorders. BACKGROUND OF THE INVENTION It is often desirable to warm or cool all or a portion of the

Devices and methods for using endovascular cooling to treat septic shock and other disorders

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FIELD OF THE INVENTION This invention relates generally to methods for medical treatment and more particularly to the use of endovascular heat exchange devices to treat sepsis, septic shock or other disorders. BACKGROUND OF THE INVENTION It is often desirable to warm or cool all or a portion of the

Substituted 5-membered ring compounds and their use

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This application is a U.S. National Stage application of co-pending PCT application PCT/GB2004/002755, filed Jun. 24, 2004, which claims the priority of Great Britain Patent Application No. 0315111.5, filed Jun. 27, 2003. These applications are incorporated herein by reference in their

Methods of treating cognitive impairment

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BACKGROUND OF THE INVENTION Memory loss has long been recognized as a common accompaniment of aging. The inabilities to recall the name of a recent acquaintance or the contents of a short shopping list are familiar experiences for everyone, and this experience seems to become more common as we

Methods of treating cognitive impairment

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BACKGROUND OF THE INVENTION Memory loss has long been recognized as a common accompaniment of aging. The inabilities to recall the name of a recent acquaintance or the contents of a short shopping list are familiar experiences for everyone, and this experience seems to become more common as we

Methods of treating cognitive impairment

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BACKGROUND OF THE INVENTION Memory loss has long been recognized as a common accompaniment of aging. The inabilities to recall the name of a recent acquaintance or the contents of a short shopping list are familiar experiences for everyone, and this experience seems to become more common as we

Use of quinone Q10 for the treatment of ocular diseases

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to the use of Coenzyme Q.sub.10 (or ubiquinone Q.sub.10 or quinone Q.sub.10, CoQ.sub.10) or functionally equivalent derivatives thereof, for the prevention, the treatment and/or attenuation of degenerative ocular

hypoxia/inflamació

Modulation of immune response and inflammation by targeting hypoxia inducible factors

Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses

Inhibition of hypoxia-inducible factor activity with carica papaya extracts

Inhibition of hypoxia-inducible factor activity with Carica papaya extracts

Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof

Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof

Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury

Method and apparatus for detection of vulnerable atherosclerotic plaque

Devices and methods for using endovascular cooling to treat septic shock and other disorders

Devices and methods for using endovascular cooling to treat septic shock and other disorders

Substituted 5-membered ring compounds and their use

Methods of treating cognitive impairment

Methods of treating cognitive impairment

Methods of treating cognitive impairment

Use of quinone Q10 for the treatment of ocular diseases

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